Gotloib L, Shostack A, Jaichenko J
Department of Nephrology, Central Emek Hospital, Afula, Israel.
Nephron. 1988;48(1):65-70. doi: 10.1159/000184872.
The peritoneum has been classically considered to be an inert passive membrane. Previous studies demonstrated the presence of fixed anionic charges at the level of the peritoneal microvasculature and the subserosal interstitium. The present study describes the selective distribution of fixed anionic charges in the mesothelial cell plasmalemma and organelles as well as in the submesothelial basal lamina of rat and mice visceral, parietal and diaphragmatic peritoneum. These data support the idea that the peritoneum should be considered a negatively charged biological dialyzing membrane with selective capabilities. Therefore, transperitoneal transfer of charged solutes cannot be analyzed just on the basis of their molecular weight, size and shape.
传统上，腹膜被认为是一种惰性的被动膜。先前的研究表明，在腹膜微血管和浆膜下间质水平存在固定阴离子电荷。本研究描述了固定阴离子电荷在大鼠和小鼠内脏、壁层和膈腹膜的间皮细胞质膜和细胞器以及间皮下基膜中的选择性分布。这些数据支持了腹膜应被视为具有选择性能力的带负电荷生物透析膜这一观点。因此，带电溶质的跨腹膜转运不能仅基于其分子量、大小和形状来分析。
