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通过核磁共振光谱法对肺炎链球菌47A血清型荚膜多糖进行结构解析。

Structural elucidation of the capsular polysaccharide from Streptococcus pneumoniae serotype 47A by NMR spectroscopy.

作者信息

Petersen Bent O, Hindsgaul Ole, Paulsen Berit Smestad, Redondo Antonio R, Skovsted Ian C

机构信息

Carlsberg Laboratory, 10 Gamle Carlsberg Vej, 1799 Copenhagen V, Denmark.

Carlsberg Laboratory, 10 Gamle Carlsberg Vej, 1799 Copenhagen V, Denmark.

出版信息

Carbohydr Res. 2014 Mar 11;386:62-7. doi: 10.1016/j.carres.2013.11.013. Epub 2013 Dec 1.

DOI:10.1016/j.carres.2013.11.013
PMID:24486982
Abstract

The structure of the serotype 47A (Danish nomenclature system) capsular polysaccharide from Streptococcus pneumoniae was elucidated by NMR spectroscopy. The following structure of the repeating heptasaccharide was deduced: [structure: see text]. The serotype 47A capsular polysaccharide is one of 91 structurally and serologically distinct capsular polysaccharides that have been recognized in S. pneumoniae, a significant human pathogenic bacterium and model system in medical microbiology. Structure and NMR spectra are compared to previously solved capsular polysaccharide structures of other serotypes.

摘要

通过核磁共振光谱法阐明了肺炎链球菌47A血清型(丹麦命名系统)荚膜多糖的结构。推导得出了以下重复七糖的结构:[结构:见原文]。47A血清型荚膜多糖是在肺炎链球菌中已识别出的91种结构和血清学上不同的荚膜多糖之一,肺炎链球菌是一种重要的人类致病细菌,也是医学微生物学中的模型系统。将该结构和核磁共振光谱与其他血清型先前解析出的荚膜多糖结构进行了比较。

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