INSERM UMRS872, Cordeliers Research Center, Immune Microenvironment and Tumours Laboratory, Paris, France; Université Paris Descartes, Paris, France; Université Pierre et Marie Curie, Paris, France.
INSERM UMRS872, Cordeliers Research Center, Immune Microenvironment and Tumours Laboratory, Paris, France; Université Paris Descartes, Paris, France; Université Pierre et Marie Curie, Paris, France; Department of Pathology, Hôpital Cochin, Paris, France.
Curr Opin Immunol. 2014 Apr;27:8-15. doi: 10.1016/j.coi.2014.01.001. Epub 2014 Feb 1.
A tumour grows in a complex microenvironment composed of stromal cells, lymphoid and myeloid cells, vascular and lymphatic vessels, and the resultant cytokine and chemokine milieu. In most primary tumours, a strong Th1/cytotoxic T cells infiltration correlates with a longer survival. This beneficial effect can be hampered by the presence of M2 polarized macrophages and high VEGF production. Recent studies revealed that the pattern of the tumour microenvironment remains a major prognostic factor even in the metastatic lesions, while been reproducible between the primary and metastatic tumour. Nevertheless the prognostic impact of the Th1/cytotoxic T cell infiltrate could be different according to the origin of the primary tumour. This model highlights a novel tumour cell-dependent immune contexture that predicts patient's clinical outcome and has implications in the use of immunotherapies.
肿瘤生长在一个由间质细胞、淋巴和髓样细胞、血管和淋巴管以及由此产生的细胞因子和趋化因子环境组成的复杂微环境中。在大多数原发性肿瘤中，强烈的 Th1/细胞毒性 T 细胞浸润与更长的生存时间相关。这种有益的效果可能会受到 M2 极化巨噬细胞和高 VEGF 产生的阻碍。最近的研究表明，即使在转移病灶中，肿瘤微环境的模式仍然是一个主要的预后因素，并且在原发性肿瘤和转移性肿瘤之间具有可重复性。然而，Th1/细胞毒性 T 细胞浸润的预后影响可能因原发性肿瘤的来源而异。该模型突出了一种新的基于肿瘤细胞的免疫结构，可预测患者的临床结局，并对免疫治疗的应用具有重要意义。
