与他莫昔芬治疗相关的类似于卵巢性索肿瘤的子宫肿瘤：病例报告及文献复习。

A uterine tumor resembling ovarian sex cord tumor associated with tamoxifen treatment: a case report and literature review.

机构信息

Departments of Pathology (A.G.-P., P.T.-Z., A.P., M.G.-C., J.P.) Gynaecology (D.R.-M., E.M.-B.), Hospital Universitario Ramón y Cajal, Madrid, Spain.

出版信息

Int J Gynecol Pathol. 2014 Mar;33(2):151-5. doi: 10.1097/PGP.0b013e318286b4d9.

DOI:10.1097/PGP.0b013e318286b4d9

PMID:24487470

Abstract

Uterine tumors resembling ovarian sex cord tumors are rare neoplasms of unknown etiology that are classified as distinct from endometrial stromal tumors on the basis of their morphologic, molecular, and behavioral characteristics. These neoplasms have a variable immunophenotype, sometimes coexpressing epithelial, myoid, and sex cord markers. To date, only 2 cases of uterine tumors resembling ovarian sex cord tumors associated with tamoxifen use have been reported. Here, we report the case of a 49-year-old woman who had been using tamoxifen for 5 years to treat breast cancer. The tumor was initially diagnosed by hysteroscopy biopsy on the basis of morphologic and immunohistochemical features. Hysterectomy revealed a polypoid mass measuring 20 mm. After an 18-month follow-up, the patient remains disease free. Here, we review the clinical, pathologic, and immunohistochemical features of uterine tumors resembling ovarian sex cord tumors and endometrial stromal tumors with a sex cord component associated with tamoxifen treatment.

摘要

类似于卵巢性索肿瘤的子宫肿瘤是一种罕见的病因不明的肿瘤，其基于形态学、分子和行为特征被归类为不同于子宫内膜间质肿瘤。这些肿瘤具有可变的免疫表型，有时共同表达上皮、肌源性和性索标志物。迄今为止，仅报道了 2 例与他莫昔芬使用相关的类似于卵巢性索肿瘤的子宫肿瘤。在这里，我们报告了 1 例 49 岁女性的病例，该患者因乳腺癌已使用他莫昔芬治疗 5 年。根据形态学和免疫组织化学特征，最初通过宫腔镜活检诊断为肿瘤。子宫切除术显示一个 20 毫米的息肉状肿块。18 个月的随访后，患者无疾病。在这里，我们回顾了与他莫昔芬治疗相关的类似于卵巢性索肿瘤和具有性索成分的子宫内膜间质肿瘤的临床、病理和免疫组织化学特征。