从 ST 段到内皮生理病理学：高胆固醇血症与内皮超氧生成。
From ST segments to endothelial pathophysiology: hypercholesterolemia and endothelial superoxide production.
出版信息
J Clin Invest. 2014 Feb;124(2):473-5. doi: 10.1172/JCI70336. Epub 2014 Feb 3.
Abstract
As a young medical resident, I encountered a patient suffering from spontaneous coronary vasospasm and was puzzled by these dramatic alterations in vasomotion. This encounter piqued my interest in understanding the drivers of vascular reactivity. In a paper published in the JCI, my colleagues and I revealed a role for superoxide production in the vascular dysfunction associated with hypercholesterolemia. Subsequent work by our group and others has unveiled complex associations between ROS generation and vascular disease.
摘要
作为一名年轻的住院医师，我遇到了一位患有自发性冠状动脉痉挛的患者，这些剧烈的血管运动变化让我感到困惑。这次经历激发了我对理解血管反应性驱动因素的兴趣。在发表于《临床研究杂志》（JCI）的一篇论文中，我和同事揭示了超氧化物产生在与高胆固醇血症相关的血管功能障碍中的作用。我们小组和其他小组的后续工作揭示了 ROS 生成与血管疾病之间复杂的关联。
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