蓝香芹酮，香芹酮的一种合成衍生物，通过减少细胞因子产生和氧化应激来抑制炎症反应，并在小鼠中显示出抗伤害感受作用。
Cyane-carvone, a synthetic derivative of carvone, inhibits inflammatory response by reducing cytokine production and oxidative stress and shows antinociceptive effect in mice.
作者信息
Marques Thiago Henrique Costa, Marques Maria Leonildes Boavista Gomes Castelo Branco, Medeiros Jand-Venes R, Silva Renan Oliveira, dos Reis Barbosa André Luiz, Lima Tamires Cardoso, de Sousa Damião Pergentino, de Freitas Rivelilson Mendes
机构信息
Laboratório de Pesquisa em Neuroquímica Experimental, Curso de Farmácia, Universidade Federal do Piauí, Campus Universitário Ministro Petrônio Portella, Bairro Ininga, 64049-550, Teresina, Piauí, Brazil.
出版信息
Inflammation. 2014 Jun;37(3):966-77. doi: 10.1007/s10753-014-9817-1.
Cyane-carvone (CC) was studied to elucidate its anti-inflammatory, antinociceptive, and antioxidant effects in Mus musculus. Anti-inflammatory (bradykinin, histamine, prostaglandin E2, serotonin, and carrageenan) and antinociceptive (acetic acid and formalin) models were utilized. Myeloperoxidase activity, interleukin (IL)-1β, tumor necrosis factor alpha (TNF-α), and glutathione (GSH) levels were evaluated. Analysis of variance followed by Student-Newman-Keuls' test was done. Results were compared with control groups (significantly when p < 0.05). In bradykinin, histamine, prostaglandin E2, and serotonin tests, 75 mg/kg CC decreased significantly paw edema (t = 30, 60, 90, and/or 120 min). In carrageenan test, 50 and 75 mg/kg CC (t = 3 h and t = 4 h) and 25 mg/kg CC (t = 4 h) decreased significantly paw edema. CC (75 mg/kg) inhibited significantly mieloperoxidase activity and decreased IL-1β and TNF-α, and all doses increased GSH levels. CC (75 mg/kg) decreased significantly the number of contortions of animals and time of licking (phase 2). CC showed anti-inflammatory, antinociceptive, and antioxidant effects in mice.
研究了蓝香芹酮（CC）对小家鼠的抗炎、镇痛和抗氧化作用。采用了抗炎（缓激肽、组胺、前列腺素E2、5-羟色胺和角叉菜胶）和镇痛（乙酸和福尔马林）模型。评估了髓过氧化物酶活性、白细胞介素（IL）-1β、肿瘤坏死因子α（TNF-α）和谷胱甘肽（GSH）水平。进行方差分析，随后进行Student-Newman-Keuls检验。将结果与对照组进行比较（p < 0.05时有显著差异）。在缓激肽、组胺、前列腺素E2和5-羟色胺试验中，75 mg/kg CC显著降低爪部水肿（t = 30、60、90和/或120分钟）。在角叉菜胶试验中，50和75 mg/kg CC（t = 3小时和t = 4小时）以及25 mg/kg CC（t = 4小时）显著降低爪部水肿。CC（75 mg/kg）显著抑制髓过氧化物酶活性并降低IL-1β和TNF-α水平，所有剂量均提高GSH水平。CC（75 mg/kg）显著减少动物的扭体次数和舔舐时间（第二阶段）。CC在小鼠中表现出抗炎、镇痛和抗氧化作用。
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