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[中高度恶性非霍奇金淋巴瘤强化联合化疗(m-BACOD方案)的初步治疗结果]

[Provisional treatment results of intensive combination chemotherapy (m-BACOD) in non-Hodgkin lymphoma of intermediate and high malignancy].

作者信息

Knecht H, Streuli R A, Odermatt B F, Rhyner K

机构信息

Departement für Innere Medizin, Univeritätsspital, Zürich.

出版信息

Schweiz Med Wochenschr. 1987 Dec 12;117(50):2038-41.

PMID:2448874
Abstract

10 patients with diffuse large cell lymphoma were treated with 10 cycles of m-BACOD. 7 patients presented with a pathological stage IV, 2 with a clinical stage III and one with a clinical stage II disease. 8 patients have been in complete remission for 3-21 months (mean 9 months) after completion of therapy. One patient with T-immunoblastic lymphoma and bulky mass died of progressive disease after 6 cycles of m-BACOD. A second patient with T-immunoblastic lymphoma relapsed 24 months after completion of therapy. Treatment-related major complications, especially MTX-related ulcerative stomatitis, did not occur.

摘要

10例弥漫性大细胞淋巴瘤患者接受了10个周期的m-BACOD方案治疗。7例患者为病理IV期,2例为临床III期,1例为临床II期疾病。8例患者在完成治疗后已完全缓解3至21个月(平均9个月)。1例患有T免疫母细胞淋巴瘤且有巨大肿块的患者在接受6个周期的m-BACOD治疗后死于疾病进展。另1例T免疫母细胞淋巴瘤患者在完成治疗24个月后复发。未发生与治疗相关的主要并发症,尤其是与甲氨蝶呤相关的溃疡性口腔炎。

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