羟基脲诱发的间质性肺炎：病例报告及文献综述

Hydroxyurea-induced interstitial pneumonitis: case report and review of the literature.

作者信息

Internullo M, Giannelli V, Sardo L, Antonaglia C, Villani T, Angelici E, Palange P

机构信息

Department of Public Health and Infectious Diseases, "Sapienza" University of Rome, Rome, Italy.

出版信息

Eur Rev Med Pharmacol Sci. 2014;18(2):190-3.

PMID:24488907

Abstract

Hydroxyurea is a cytotoxic agent widely used in the treatment of myeloproliferative disorders. It is considered a-well-tolerated antineoplastic drug, with a dose-related bone marrow suppression as main adverse effect. This report describes a patient with essential thrombocythemia who developed an interstitial pneumonitis and respiratory failure within 4 years from beginning therapy with hydroxyurea (HU). After discontinuing of HU. both clinical and radiological resolution of pneumonitis occurred. In conclusion, HU-induced pulmonary toxicity is a potentially life-threatening side effect.

摘要

羟基脲是一种细胞毒性药物，广泛用于治疗骨髓增殖性疾病。它被认为是一种耐受性良好的抗肿瘤药物，主要不良反应是与剂量相关的骨髓抑制。本报告描述了一名原发性血小板增多症患者，在开始使用羟基脲（HU）治疗后4年内发生了间质性肺炎和呼吸衰竭。停用HU后，肺炎的临床和影像学表现均得到缓解。总之，HU引起的肺部毒性是一种潜在的危及生命的副作用。