Pandit Anjali U, Bailey Stacy C, Curtis Laura M, Seligman Hilary K, Davis Terry C, Parker Ruth M, Schillinger Dean, DeWalt Darren, Fleming David, Mohr David C, Wolf Michael S
Department of General Internal Medicine, Health Literacy and Learning Program, Feinberg School of Medicine, , Chicago, Illinois, USA.
J Epidemiol Community Health. 2014 Jun;68(6):557-64. doi: 10.1136/jech-2013-203063. Epub 2014 Jan 31.
The purpose of this study is to determine the prevalence of diabetes distress and its relationship with health behaviours and clinical outcomes in low-income patients.
Secondary analyses were conducted using baseline data from a clinical trial evaluating a diabetes self-management intervention. Interviews were conducted with 666 participants receiving care at nine safety net clinics in Missouri. Distress was measured using the Diabetes Distress Scale, and outcomes included medication adherence, physical activity, nutrition and clinical biomarkers (haemoglobin A1C (HbA1C), blood pressure, low-density lipoprotein (LDL) cholesterol).
In a sample of 666 participants, 14.1% and 27.3% of patients were identified as highly and moderately distressed, respectively, with higher rates among younger, female and lower income patients. When compared with moderately and no distress groups, highly distressed patients were less adherent to medications (20.7% vs 29.9% vs 39.4%, p<0.001) and had higher HbA1C values (9.3% (SD=2.0) vs 8.2% (SD=1.8) vs 7.8% (SD=1.7), p<0.001), diastolic blood pressure (81.8 (SD=9.4) vs 80.2 (9.7) vs 78.9 (SD=8.8), p=0.02) and LDL cholesterol (104.6 (SD=42.4) vs 97.2 (34.3) vs 95.5 (37.9)) In multivariable analyses, high and moderate distress were associated with lower medication adherence (OR=0.44; 0.27 to 0.23, p=0.001) and (OR=0.58; 0.42 to 0.79; p=0.001), respectively, and higher HbA1C in only the highly distressed group (B=1.3; 0.81 to 1.85; p<0.001) compared with the no distress group.
Diabetes distress is prevalent and linked to poorer adherence to health behaviours and glycemic control in a sample of patients receiving care from low-income clinics.
本研究旨在确定低收入患者中糖尿病困扰的患病率及其与健康行为和临床结局的关系。
使用一项评估糖尿病自我管理干预措施的临床试验的基线数据进行二次分析。对在密苏里州9家安全网诊所接受治疗的666名参与者进行了访谈。使用糖尿病困扰量表测量困扰程度,结局指标包括药物依从性、身体活动、营养状况和临床生物标志物(糖化血红蛋白(HbA1C)、血压、低密度脂蛋白(LDL)胆固醇)。
在666名参与者的样本中,分别有14.1%和27.3%的患者被确定为高度困扰和中度困扰,年轻、女性和低收入患者的比例更高。与中度困扰组和无困扰组相比,高度困扰的患者药物依从性更低(20.7%对29.9%对39.4%,p<0.001),HbA1C值更高(9.3%(标准差=2.0)对8.2%(标准差=1.8)对7.8%(标准差=1.7),p<0.001),舒张压(81.8(标准差=9.4)对80.2(9.7)对78.9(标准差=8.8),p=0.02)和LDL胆固醇(104.6(标准差=42.4)对97.2(34.3)对95.5(37.9))。在多变量分析中,高度困扰和中度困扰分别与较低的药物依从性相关(比值比=0.44;0.27至0.23,p=0.001)和(比值比=0.58;0.42至0.79;p=0.001),并且与无困扰组相比,仅高度困扰组的HbA1C更高(B=1.3;0.81至1.85;p<0.001)。
在从低收入诊所接受治疗的患者样本中,糖尿病困扰普遍存在,并且与较差的健康行为依从性和血糖控制相关。