Szulczyk Daniel, Bielenica Anna, Dobrowolski Michał A, Dobrzycki Lukasz, Krawiecka Mariola, Kuran Bożena, Struga Marta
Department of Medical Chemistry, Faculty of Medicine, Medical University of Warsaw, Oczki 3 Street, 02-007 Warsaw, Poland.
Faculty of Chemistry, University of Warsaw, Pasteura 1 Street, 02-093 Warsaw, Poland.
Med Chem Res. 2014;23(3):1519-1536. doi: 10.1007/s00044-013-0740-z. Epub 2013 Sep 3.
A series of arylpiperazine derivatives of 1,16-diphenyl-19-azahexacyclo-[14.5.1.0.0.0.0]docosa-2,3,5,7,8,9,11,13,14-nonaene-18,20,22-trione and 4,10-diphenyl-1,2,3,5-indeno[1,2-]isoindole-1,3,5-trione was synthesized. The pharmacological profile of compound at the 5-HT receptor was measured by binding assay. The title compounds were tested in cell-based assay against the human immunodeficiency virus type-1. The X-ray crystallographic studies of derivatives , , , , , and were presented.
合成了一系列1,16 - 二苯基 - 19 - 氮杂十六环 - [14.5.1.0.0.0.0]二十二碳 - 2,3,5,7,8,9,11,13,14 - 九烯 - 18,20,22 - 三酮和4,10 - 二苯基 - 1,2,3,5 - 茚并[1,2 - ]异吲哚 - 1,3,5 - 三酮的芳基哌嗪衍生物。通过结合试验测定了化合物在5 - HT受体上的药理学特征。对标题化合物进行了针对1型人类免疫缺陷病毒的基于细胞的试验。给出了衍生物、、、、、和的X射线晶体学研究结果。
