Mironneau J
Laboratoire de Physiologie Cellulaire, Centre National de la Recherche Scientifique, Universite de Bordeaux II, France.
Am J Med. 1988 Jan 29;84(1B):10-4.
The effects of indapamide on ionic currents and isometric contractions in both rat myometrium and rat portal vein preparations were studied. Indapamide (3 x 10(-4) M) depressed both inward calcium and outward potassium currents. The decrease in potassium current was dependent on the reduction of the inward calcium current. Indapamide reduced the transient contraction induced in calcium-free, ethylene glycol-bis(B-aminoethylether)-N,N'tetra-acetic acid-containing solutions by either acetylcholine (10(-4) M) or norepinephrine (10(-5) M). The results indicate that indapamide acts primarily on the plasma membrane of spontaneously active smooth muscles by reducing the calcium current; it may also depress contractions supported by release of calcium from the sarcoplasmic reticulum.
研究了吲达帕胺对大鼠子宫肌层和大鼠门静脉制剂中离子电流和等长收缩的影响。吲达帕胺（3×10⁻⁴ M）可抑制内向钙电流和外向钾电流。钾电流的降低依赖于内向钙电流的减少。吲达帕胺可降低由乙酰胆碱（10⁻⁴ M）或去甲肾上腺素（10⁻⁵ M）在无钙、含乙二醇双（β-氨基乙基醚）-N，N'-四乙酸的溶液中诱导的瞬时收缩。结果表明，吲达帕胺主要通过降低钙电流作用于自发活动平滑肌的质膜；它也可能抑制由肌浆网释放钙所支持的收缩。
