免疫抑制消除了幼兔对兔出血症（RHD）的抵抗力。
Immunosuppression abrogates resistance of young rabbits to Rabbit Haemorrhagic Disease (RHD).
机构信息
Department of Anatomy, ICBAS (Abel Salazar Institute for Biomedical Science) and UMIB (Unit for Multidisciplinary Biomedical Research), University of Porto, Rua de Jorge Viterbo Ferreira n,° 228, 4050-313 Porto, Portugal.
出版信息
Vet Res. 2014 Feb 4;45(1):14. doi: 10.1186/1297-9716-45-14.
Rabbit Haemorrhagic Disease (RHD) is caused by a calicivirus (RHDV) that kills 90% of infected adult European rabbits within 3 days. Remarkably, young rabbits are resistant to RHD. We induced immunosuppression in young rabbits by treatment with methylprednisolone acetate (MPA) and challenged the animals with RHDV by intramuscular injection. All of these young rabbits died within 3 days of infection due to fulminant hepatitis, presenting a large number of RHDV-positive dead or apoptotic hepatocytes, and a significant seric increase in cytokines, features that are similar to those of naïve adult rabbits infected by RHDV. We conclude that MPA-induced immunosuppression abrogates the resistance of young rabbits to RHD, indicating that there are differences in the innate immune system between young and adult rabbits that contribute to their distinct resistance/susceptibility to RHDV infection.
兔出血症（RHD）是由兔出血症病毒（RHDV）引起的，感染该病毒的成年兔 90%在 3 天内死亡。而令人惊讶的是，幼兔对 RHD 具有抵抗力。我们通过醋酸甲泼尼龙（MPA）处理诱导幼兔免疫抑制，并通过肌肉注射用 RHDV 对动物进行攻击。所有这些幼兔在感染后 3 天内因暴发性肝炎而死亡，表现出大量 RHDV 阳性的坏死或凋亡肝细胞，以及细胞因子的显著血清学增加，这些特征与感染 RHDV 的新生成年兔相似。我们得出结论，MPA 诱导的免疫抑制破坏了幼兔对 RHD 的抵抗力，表明幼兔和成年兔的先天免疫系统存在差异，这导致了它们对 RHDV 感染的不同抵抗力/易感性。
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