Barnes Deborah E, Beiser Alexa S, Lee Anne, Langa Kenneth M, Koyama Alain, Preis Sarah R, Neuhaus John, McCammon Ryan J, Yaffe Kristine, Seshadri Sudha, Haan Mary N, Weir David R
Department of Psychiatry, University of California, San Francisco, CA, USA; Department of Epidemiology & Biostatistics, University of California, San Francisco, CA, USA; Veterans Affairs Medical Center, San Francisco, CA, USA.
Department of Neurology, Boston University, Boston, MA, USA; Department of Biostatistics, Boston University, Boston, MA, USA.
Alzheimers Dement. 2014 Nov;10(6):656-665.e1. doi: 10.1016/j.jalz.2013.11.006. Epub 2014 Feb 1.
Detection of "any cognitive impairment" is mandated as part of the Medicare annual wellness visit, but screening all patients may result in excessive false positives.
We developed and validated a brief Dementia Screening Indicator using data from four large, ongoing cohort studies (the Cardiovascular Health Study [CHS]; the Framingham Heart Study [FHS]; the Health and Retirement Study [HRS]; the Sacramento Area Latino Study on Aging [SALSA]) to help clinicians identify a subgroup of high-risk patients to target for cognitive screening.
The final Dementia Screening Indicator included age (1 point/year; ages, 65-79 years), less than 12 years of education (9 points), stroke (6 points), diabetes mellitus (3 points), body mass index less than 18.5 kg/m(2) (8 points), requiring assistance with money or medications (10 points), and depressive symptoms (6 points). Accuracy was good across the cohorts (Harrell's C statistic: CHS, 0.68; FHS, 0.77; HRS, 0.76; SALSA, 0.78).
The Dementia Screening Indicator is a simple tool that may be useful in primary care settings to identify high-risk patients to target for cognitive screening.
作为医疗保险年度健康检查的一部分,要求对“任何认知障碍”进行检测,但对所有患者进行筛查可能会导致过多的假阳性结果。
我们利用四项大型正在进行的队列研究(心血管健康研究[CHS];弗雷明汉心脏研究[FHS];健康与退休研究[HRS];萨克拉门托地区拉丁裔老龄化研究[SALSA])的数据,开发并验证了一种简短的痴呆筛查指标,以帮助临床医生识别出高风险患者亚组,作为认知筛查的目标人群。
最终的痴呆筛查指标包括年龄(每年1分;年龄65 - 79岁)、受教育年限少于12年(9分)、中风(6分)、糖尿病(3分)、体重指数低于18.5 kg/m²(8分)、需要在金钱或药物方面得到帮助(10分)以及抑郁症状(6分)。在各个队列中,该指标的准确性良好(Harrell's C统计量:CHS为0.68;FHS为0.77;HRS为0.76;SALSA为0.78)。
痴呆筛查指标是一种简单的工具,可能有助于在初级保健环境中识别出作为认知筛查目标的高风险患者。