Andrus Gerontology Center, University of Southern California, Los Angeles, CA 90089-0191, USA.
J Gerontol B Psychol Sci Soc Sci. 2011 Jul;66 Suppl 1(Suppl 1):i162-71. doi: 10.1093/geronb/gbr048.
This study examines the similarity of cognitive assessments using 1 interview in a large population study, the Health and Retirement Study (HRS), and a subsample in which a detailed neuropsychiatric assessment has been performed (Aging, Demographics, and Memory Study [ADAMS]).
Respondents are diagnosed in ADAMS as demented, cognitively impaired without dementia (CIND), or as having normal cognitive function. Multinomial logistic analysis is used to predict diagnosis using a variety of cognitive and noncognitive measures from the HRS and additional measures and information from ADAMS.
The cognitive tests in HRS predict the ADAMS diagnosis in 74% of the sample able to complete the HRS survey on their own. Proxy respondents answer for a large proportion of HRS respondents who are diagnosed as demented in ADAMS. Classification of proxy respondents with some cognitive impairment can be predicted in 86% of the sample. Adding a small number of additional tests from ADAMS can increase each of these percentages to 84% and 93%, respectively.
Cognitive assessment appropriate for diagnosis of dementia and CIND in large population surveys could be improved with more targeted information from informants and additional cognitive tests targeting other areas of brain function.
本研究通过对大型人群研究（健康与退休研究，HRS）中的 1 次访谈与一个已进行详细神经精神评估的子样本（老龄化、人口统计学和记忆研究，ADAMS）中的认知评估进行比较，考察认知评估的相似性。
ADAMS 将受访者诊断为痴呆、无痴呆认知障碍（CIND）或认知功能正常。采用多项逻辑回归分析，使用 HRS 中的各种认知和非认知测量以及 ADAMS 中的其他测量和信息，预测诊断。
在能够独立完成 HRS 调查的样本中，HRS 中的认知测试可预测 ADAMS 诊断，占 74%。ADAMS 中诊断为痴呆的大多数 HRS 受访者由代理人回答。在样本中，86%的代理人有一定认知障碍的分类可以预测。从 ADAMS 中添加少量额外测试可以将这两个百分比分别提高到 84%和 93%。
对于大型人群调查中的痴呆和 CIND 诊断，更有针对性的知情者信息和针对大脑其他功能领域的额外认知测试可以改进认知评估。
