关键基因和通路在恶性间皮瘤肿瘤发生中的作用。
The role of key genes and pathways involved in the tumorigenesis of Malignant Mesothelioma.
作者信息
de Assis Leonardo Vinícius Monteiro, Locatelli Jamille, Isoldi Mauro César
机构信息
Laboratory of Hypertension, Campus Universitário Morro do Cruzeiro, Brazil; Pharmacy School, Federal University of Ouro Preto, Minas Gerais, Brazil.
Laboratory of Hypertension, Campus Universitário Morro do Cruzeiro, Brazil; Núcleo de Pesquisa em Ciências Biológicas (NUPEB), Universidade Federal de Ouro Preto, Ouro Preto, MG, Brazil.
出版信息
Biochim Biophys Acta. 2014 Apr;1845(2):232-47. doi: 10.1016/j.bbcan.2014.01.008. Epub 2014 Jan 31.
Malignant Mesothelioma (MM) is a very aggressive cancer with low survival rates and often diagnosed at an advanced stage. Several players have been implicated in the development of this cancer, such as asbestos, erionite and the simian virus 40 (SV40). Here, we have reviewed the involvement of erionite, SV40, as well as, the role of several genes (p16(INK4a), p14(ARF), NF2, LATS2, SAV, CTNNB1 and among others), the pathways (RAS, PI3K, Wnt, BCL and Hippo), and their respective roles in the development of MM.
恶性间皮瘤（MM）是一种侵袭性很强的癌症，生存率低，且常于晚期被诊断出来。多种因素与这种癌症的发生有关，如石棉、毛沸石和猿猴病毒40（SV40）。在此，我们综述了毛沸石、SV40的影响，以及几个基因（p16(INK4a)、p14(ARF)、NF2、LATS2、SAV、CTNNB1等）、信号通路（RAS、PI3K、Wnt、BCL和Hippo）及其在恶性间皮瘤发生中的各自作用。
Zotero 插件