Scaria George S, Kren Betsy T, Klein Mark A
Research Service, Minneapolis VA Health Care System, Minneapolis, MN 55417, USA.
Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA.
Pharmaceuticals (Basel). 2020 Feb 5;13(2):26. doi: 10.3390/ph13020026.
Pancreatic cancer, hepatocellular carcinoma (HCC), and mesothelioma are treatment-refractory cancers, and patients afflicted with these cancers generally have a very poor prognosis. The genomics of these tumors were analyzed as part of The Cancer Genome Atlas (TCGA) project. However, these analyses are an overview and may miss pathway interactions that could be exploited for therapeutic targeting. In this study, the TCGA Pan-Cancer datasets were queried via cBioPortal for correlations among mRNA expression of key genes in the cell cycle and mitochondrial (mt) antioxidant defense pathways. Here we describe these correlations. The results support further evaluation to develop combination treatment strategies that target these two critical pathways in pancreatic cancer, hepatocellular carcinoma, and mesothelioma.
胰腺癌、肝细胞癌（HCC）和间皮瘤是难治性癌症，罹患这些癌症的患者总体预后通常很差。作为癌症基因组图谱（TCGA）项目的一部分，对这些肿瘤的基因组学进行了分析。然而，这些分析只是一个概述，可能会遗漏可用于治疗靶点的信号通路相互作用。在本研究中，通过cBioPortal查询TCGA泛癌数据集，以寻找细胞周期关键基因的mRNA表达与线粒体（mt）抗氧化防御信号通路之间的相关性。在此我们描述这些相关性。结果支持进一步评估，以制定针对胰腺癌、肝细胞癌和间皮瘤这两个关键信号通路的联合治疗策略。
