Sivanesaratnam V, Sen D K, Jayalakshmi P
Department of Obstetrics and Gynaecology, University of Malaya, Kuala Lumpur.
Aust N Z J Obstet Gynaecol. 1987 Aug;27(3):231-3. doi: 10.1111/j.1479-828x.1987.tb00995.x.
Patients at high risk of recurrence or metastases following radical surgery for Stage 1B and 2A cervical carcinoma include those with pelvic node metastases, lymphatic or vascular space permeation in the cervix by tumour cells, large size of the primary tumour, involvement of the full thickness of the cervix and parametrial spread. We report the initial results of adjuvant chemotherapy using a combination of cisplatinum, bleomycin and vinblastine in 22 patients who had undergone Wertheim radical hysterectomy and were thought to be at high risk of developing recurrence. The mean duration of follow-up was 23 months. All are alive after follow-up ranging from 13 to 43 months. Three patients developed recurrences--one in the pelvis, another at the posterior aspect of the urethral meatus and the third developed pulmonary secondaries at 20 to 23 months after surgery. Toxicity from the chemotherapy was acceptable.
对于1B期和2A期宫颈癌根治术后有复发或转移高风险的患者，包括那些有盆腔淋巴结转移、肿瘤细胞浸润宫颈淋巴管或血管间隙、原发肿瘤体积大、宫颈全层受累以及宫旁组织扩散的患者。我们报告了22例接受了韦特海姆根治性子宫切除术且被认为有高复发风险的患者使用顺铂、博来霉素和长春碱联合进行辅助化疗的初步结果。平均随访时间为23个月。随访13至43个月后所有患者均存活。3例患者出现复发——1例在盆腔，另1例在尿道口后方，第3例在术后20至23个月出现肺部继发性肿瘤。化疗的毒性是可接受的。
