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在使用厚锂靶和高斯质子能量进行硼中子俘获治疗(BNCT)的实际条件下的近阈(7)锂(p,n)(7)铍中子

Near-threshold (7)Li(p,n)(7)Be neutrons on the practical conditions using thick Li-target and Gaussian proton energies for BNCT.

作者信息

Kobayashi Tooru, Hayashizaki Noriyosu, Katabuchi Tatsuya, Tanaka Kenichi, Bengua Gerard, Nakao Noriaki, Kosako Kazuaki

机构信息

Kyoto University Research Reactor Institute, Osaka 590-0494, Japan.

Research Laboratory for Nuclear Reactors, Tokyo Institute of Technology, Tokyo, Japan.

出版信息

Appl Radiat Isot. 2014 Jun;88:221-4. doi: 10.1016/j.apradiso.2013.12.024. Epub 2014 Jan 8.

Abstract

The near threshold (7)Li(p,n)(7)Be neutrons generated by incident proton energy having Gaussian distribution with mean energies from 1.85 to 1.95MeV, were studied as a practical neutron source for BNCT wherein an RFQ accelerator and a thick Li-target are used. Gaussian energy distributions with the standard deviation of 0, 10, 20 and 40keV for mean proton energies from 1.85 to 1.95MeV were surveyed in 0.01MeV increments. A thick liquid Li-target whose dimensions were established in our previous experiments (i.e., 1mm-thick with 50mm width and 50mm length) was considered in this study. The suitable incident proton energy and physical dimensions of Pb layer which serves as a gamma absorber and a Polyethylene layer which is used as a BDE were surveyed by means of the concepts of TPD. Dose distribution were calculated by using MCNP5. A proton beam with mean energy of 1.92MeV and a Gaussian energy distribution with a standard deviation of 20keV at a current of 10mA was selected from the viewpoint of irradiation time and practically achievable proton current. The suitable thicknesses of Pb gamma absorber was estimated to be about 3cm. The estimated thickness of the polyethylene BDE was about 24mm for an ideal proton current of 13mA, and was 18mm for a practical proton current of 10mA.

摘要

研究了由平均能量在1.85至1.95MeV之间且具有高斯分布的入射质子能量所产生的近阈(7)Li(p,n)(7)Be中子,将其作为硼中子俘获疗法(BNCT)的一种实用中子源,其中使用了射频四极加速器(RFQ)和厚锂靶。对平均质子能量从1.85至1.95MeV、标准差分别为0、10、20和40keV的高斯能量分布,以0.01MeV的增量进行了研究。本研究考虑了一个厚液态锂靶,其尺寸是在我们之前的实验中确定的(即1mm厚、50mm宽和50mm长)。借助传输概率分布(TPD)的概念,研究了用作γ射线吸收体的铅层以及用作硼剂量增强器(BDE)的聚乙烯层的合适入射质子能量和物理尺寸。使用MCNP5计算剂量分布。从辐照时间和实际可实现的质子电流的角度出发,选择了平均能量为1.92MeV、标准差为20keV且电流为10mA的高斯能量分布的质子束。估计合适的铅γ射线吸收体厚度约为3cm。对于理想质子电流13mA,估计的聚乙烯硼剂量增强器厚度约为24mm,对于实际质子电流10mA,其厚度为18mm。

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