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分泌性中耳炎患儿的晚期氧化蛋白产物水平

Advanced oxidation protein product level in children with chronic otitis media with effusion.

作者信息

Balıkcı Hasan Huseyin, Karakaş Mustafa, Gürdal Muhammet Mustafa, Ozkul Murat Haluk, Bayram Ozlem, Bayram Ali Alper, Yigit Servet

机构信息

Department of Otorhinolaryngology, Susehri Government Hospital, Sivas, Turkey.

Department of Otorhinolaryngology, Haseki Research and Training Hospital, Istanbul, Turkey.

出版信息

Int J Pediatr Otorhinolaryngol. 2014 Mar;78(3):551-3. doi: 10.1016/j.ijporl.2014.01.007. Epub 2014 Jan 16.

Abstract

OBJECTIVE

To determine the level of advanced oxidation protein products (AOPPs) in children with chronic otitis media with effusion (COME), in an effort to elucidate the multifactorial etiology of this disease.

METHODS

This study involved 25 COME patients and 30 healthy children (control group) recruited from the Ear, Nose and Throat (ENT) and Pediatric Departments, respectively, of the Haseki Research and Training Hospital. In the COME group, blood samples were collected before a middle ear operation, and middle ear fluid was sampled during the operation. Blood samples were also obtained from the control subjects. AOPP levels in the plasma and effusion fluid were measured by the spectrophotometric method.

RESULTS

In the COME group, the mean AOPP levels in plasma and effusion fluid were 168.08 μmol/l and 412.75 μmol/l, respectively. In the control group, the mean plasma AOPP level was 141.54 μmol/l. The plasma AOPP levels did not significantly differ between the COME and control groups (p>0.05). In the COME group, however, the effusion fluid AOPP level (412.75 ± 204.54 μmol/l) was significantly higher than the plasma AOPP level (168.08 ± 68.45 μmol/l; p<0.01).

CONCLUSION

We found that AOPP levels were elevated in the effusion fluid, but not in the plasma, of COME patients. Thus, COME was associated with protein oxidation abnormalities. Oxidative stress may play a role in the etiopathogenesis of COME, and AOPPs may be used as markers of oxidative stress; however, further studies are required to confirm these findings.

摘要

目的

测定分泌性中耳炎(COME)患儿体内晚期氧化蛋白产物(AOPPs)水平,以阐明该疾病的多因素病因。

方法

本研究纳入了分别来自哈塞基研究与培训医院耳鼻喉科(ENT)和儿科的25例COME患者及30名健康儿童(对照组)。COME组在中耳手术前采集血样,手术期间采集中耳积液样本。对照组也采集血样。采用分光光度法测定血浆和积液中的AOPP水平。

结果

COME组血浆和积液中AOPP的平均水平分别为168.08μmol/l和412.75μmol/l。对照组血浆AOPP平均水平为141.54μmol/l。COME组与对照组血浆AOPP水平无显著差异(p>0.05)。然而,COME组积液中AOPP水平(412.75±204.54μmol/l)显著高于血浆AOPP水平(168.08±68.45μmol/l;p<0.01)。

结论

我们发现COME患者的积液中AOPP水平升高,而血浆中未升高。因此,COME与蛋白质氧化异常有关。氧化应激可能在COME的发病机制中起作用,AOPPs可能作为氧化应激的标志物;然而,需要进一步研究来证实这些发现。

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