Ke Raymond W
Assisted Reproduction, Fertility Associates of Memphis, 80 Humphreys Center, Suite 307, Memphis, TN 38120, USA.
Obstet Gynecol Clin North Am. 2014 Mar;41(1):103-12. doi: 10.1016/j.ogc.2013.10.003. Epub 2013 Dec 5.
Common endocrinopathies are a frequent contributor to spontaneous and recurrent miscarriage. Although the diagnostic criteria for luteal phase defect (LPD) is still controversial, treatment of patients with both recurrent pregnancy loss and LPD using progestogen in early pregnancy seems beneficial. For patients who are hypothyroid, thyroid hormone replacement therapy along with careful monitoring in the preconceptual and early pregnancy period is associated with improved outcome. Women with polycystic ovary syndrome (PCOS) have an increased risk of pregnancy loss. Management of PCOS with normalization of weight or metformin seems to reduce the risk of pregnancy loss.
常见的内分泌疾病是导致自然流产和复发性流产的常见原因。尽管黄体期缺陷（LPD）的诊断标准仍存在争议，但对复发性流产且患有LPD的患者在孕早期使用孕激素进行治疗似乎有益。对于甲状腺功能减退的患者，在孕前和孕早期进行甲状腺激素替代治疗并仔细监测，与改善结局相关。多囊卵巢综合征（PCOS）女性的流产风险增加。通过控制体重正常化或使用二甲双胍治疗PCOS似乎可以降低流产风险。
