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三尖瓣修复术预防功能性三尖瓣反流。

"Prophylactic" tricuspid repair for functional tricuspid regurgitation.

机构信息

Department of Cardiac Surgery, University of Michigan Health System, Ann Arbor, Michigan.

Department of Cardiac Surgery, University of Michigan Health System, Ann Arbor, Michigan.

出版信息

Ann Thorac Surg. 2014 May;97(5):1520-4. doi: 10.1016/j.athoracsur.2013.11.049. Epub 2014 Feb 1.

Abstract

BACKGROUND

The optimal management of functional tricuspid regurgitation (FTR) in the setting of mitral valve operations remains controversial. The objective of this study is to compare the outcomes of congestive heart failure patients who underwent a prophylactic tricuspid operation for FTR as a component of their initial mitral valve procedure with those who underwent a redo tricuspid operation at a later date for residual FTR.

METHODS

Patients with FTR repaired as a redo operation between 2004 and 2012 were identified. These patients were propensity-matched 1:2 with contemporaneous patients with FTR or tricuspid dilatation who underwent tricuspid repair at the same time as mitral valve repair. Demographic information, postoperative complications, and short-term and long-term mortality rates were compared between groups.

RESULTS

There were 21 patients treated with redo tricuspid valve repair matched with 42 patients treated prophylactically. There were 3 deaths at 30 days in the redo group (14%), compared with zero in the prophylactic group (p=0.03). Overall long-term mortality in the redo group was 29% (6 of 21), with a mean 31 months of follow-up, but was only 14% (6 of 42) in the prophylactic group, with a mean 25 months of follow-up. Kaplan-Meier long-term survival analysis did not reveal a difference between groups (log-rank p=0.37) once the perioperative period was survived.

CONCLUSIONS

Redo tricuspid valve repair for residual FTR can be performed with acceptable short-term and long-term mortality. However, treatment of FTR at the time of the initial intervention should be considered, because it is safe and effective. A randomized, controlled trial of prophylactic tricuspid operation for FTR at the time of the mitral operation may be warranted.

摘要

背景

在二尖瓣手术中,功能性三尖瓣反流(FTR)的最佳治疗方法仍存在争议。本研究旨在比较因 FTR 行预防性三尖瓣手术(作为初始二尖瓣手术的一部分)的充血性心力衰竭患者与因残余 FTR 行后期三尖瓣再手术的患者的结局。

方法

确定了 2004 年至 2012 年期间行 FTR 再手术的患者。将这些患者与同期行 FTR 或三尖瓣扩张修复术且同时行二尖瓣修复术的患者进行 1:2 倾向性匹配。比较两组患者的人口统计学资料、术后并发症、短期和长期死亡率。

结果

再手术组中有 21 例患者接受了三尖瓣再修复术,与之匹配的是同期行预防性三尖瓣修复术的 42 例患者。再手术组 30 天内有 3 例死亡(14%),而预防性组无死亡(p=0.03)。再手术组的总体长期死亡率为 29%(21 例中的 6 例),中位随访时间为 31 个月,但预防性组仅为 14%(42 例中的 6 例),中位随访时间为 25 个月。Kaplan-Meier 长期生存分析显示,一旦度过围手术期,两组间无差异(对数秩检验 p=0.37)。

结论

对于残余 FTR,行三尖瓣再修复术可获得可接受的短期和长期死亡率。然而,应该考虑在初始干预时治疗 FTR,因为它是安全有效的。对于在二尖瓣手术时预防性行三尖瓣手术治疗 FTR 的随机对照试验可能是必要的。

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