有效的传染的结构基础：麻疹病毒对副流感病毒主题的变异。
Structural basis of efficient contagion: measles variations on a theme by parainfluenza viruses.
机构信息
Department of Molecular Medicine, Mayo Clinic, and Virology and Gene Therapy Track, Mayo Graduate School, 200 First Street SW, Rochester, MN 55905, USA.
Department of Molecular Medicine, Mayo Clinic, and Virology and Gene Therapy Track, Mayo Graduate School, 200 First Street SW, Rochester, MN 55905, USA.
出版信息
Curr Opin Virol. 2014 Apr;5:16-23. doi: 10.1016/j.coviro.2014.01.004. Epub 2014 Feb 1.
A quartet of attachment proteins and a trio of fusion protein subunits play the cell entry concert of parainfluenza viruses. While many of these viruses bind sialic acid to enter cells, wild type measles binds exclusively two tissue-specific proteins, the lymphatic receptor signaling lymphocytic activation molecule (SLAM), and the epithelial receptor nectin-4. SLAM binds near the stalk-head junction of the hemagglutinin. Nectin-4 binds a hydrophobic groove located between blades 4 and 5 of the hemagglutinin β-propeller head. The mutated vaccine strain hemagglutinin binds in addition the ubiquitous protein CD46, which explains attenuation. The measles virus entry concert has four movements. Andante misterioso: the virus takes over the immune system. Allegro con brio: it rapidly spreads in the upper airway's epithelia. 'Targeting' fugue: the versatile orchestra takes off. Presto furioso: the virus exits the host with thunder. Be careful: music is contagious.
四attachment 蛋白和三个融合蛋白亚基在副流感病毒的细胞进入过程中发挥作用。虽然许多这些病毒通过结合唾液酸进入细胞，但野毒株麻疹病毒只特异性地结合两种组织特异性蛋白，即淋巴受体信号淋巴细胞激活分子（SLAM）和上皮受体 nectin-4。SLAM 结合在血凝素的茎干-头部连接处附近。nectin-4 结合位于血凝素 β-推进器头部的第 4 和第 5 个叶片之间的疏水槽。突变的疫苗株血凝素除了结合无处不在的蛋白 CD46 之外，还解释了减毒现象。麻疹病毒进入过程有四个乐章。Andante misterioso：病毒接管免疫系统。Allegro con brio：它在上呼吸道上皮中迅速传播。'Targeting' fugue：多功能管弦乐队起飞。Presto furioso：病毒带着雷鸣般的声音离开宿主。小心：音乐具有传染性。
Zotero 插件