Ram R, Swarnalatha G, Dakshinamurty K V
Nizam's Insitute of Medical Sciences, Hyderabad, AP, India,
J Nephrol. 2014 Aug;27(4):445-9. doi: 10.1007/s40620-014-0048-1. Epub 2014 Feb 4.
A high proportion of patients whose catheters are removed are unable to successfully reinitiate peritoneal dialysis (PD) due to irreversible peritoneal injury or to decisions made by the patient or the nephrologist for different and often empiric reasons. The present study examined the outcomes of patients reinitiated on PD after peritonitis.
We reviewed all patients with end-stage renal disease who were initiated on continuous ambulatory peritoneal dialysis at our Institute in south India between 1998 and 2012, identifying those in whom the catheter was removed and the cases where PD was reinitiated, analysing the reasons and outcome. We compared data of patients who could be reinitiated on PD with those who could not be reinitiated and also data of patients who successfully continued PD after reinitiation with those who suffered technique failure.
Peritoneal dialysis was reinitiated in 31 (19.4%) of 159 patients whose catheter was removed owing to refractory peritonitis, including after an episode of Pseudomonas aeruginosa and fungal peritonitis. Some patients had the catheter placed for a third time. No significant difference was found between patients who reinitiated PD vs. did not, or between those who were successful in reinitiating PD vs. unsuccessful.
Notwithstanding the small cohort size, the present study demonstrates that reinitiating PD is feasible in a developing country, and also that reinitiation of PD is possible after an episode of P. aeruginosa and fungal peritonitis. However, future studies in a larger patient cohort and assessing dialysis adequacy are required to confirm and extend our findings.
很大一部分导管被拔除的患者由于不可逆转的腹膜损伤,或由于患者或肾病科医生出于不同且通常是经验性的原因所做的决定,而无法成功重新开始腹膜透析(PD)。本研究调查了腹膜炎后重新开始PD的患者的结局。
我们回顾了1998年至2012年期间在印度南部我们研究所开始接受持续性非卧床腹膜透析的所有终末期肾病患者,确定那些导管被拔除的患者以及重新开始PD的病例,分析原因和结局。我们将能够重新开始PD的患者的数据与无法重新开始的患者的数据进行了比较,并且还将重新开始后成功继续PD的患者的数据与那些遭受技术失败的患者的数据进行了比较。
159例因难治性腹膜炎而拔除导管的患者中有31例(19.4%)重新开始了腹膜透析,包括在发生铜绿假单胞菌和真菌性腹膜炎之后。一些患者第三次置入了导管。重新开始PD的患者与未重新开始的患者之间,以及成功重新开始PD的患者与未成功的患者之间均未发现显著差异。
尽管队列规模较小,但本研究表明在发展中国家重新开始PD是可行的,并且在发生铜绿假单胞菌和真菌性腹膜炎之后重新开始PD也是可能的。然而,需要在更大的患者队列中进行进一步研究并评估透析充分性,以证实和扩展我们的发现。