Blaszczyk B, Karakoz I, Gieldanowski J, Katkiewicz M, Viljanen M
Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw.
Folia Biol (Praha). 1987;33(6):385-99.
Chickens of the inbred IA line develop clinical signs of experimental allergic encephalomyelitis (EAE) after immunization with myelin basic protein (MP) or spinal cord tissue (SCT). The disease is accompanied by convulsions and paralysis of wings and legs. EAE leads to a 100% mortality in IA line chickens. On the other hand, no clinical signs appear in WA line and (CB x IA) F1 chickens following immunization with either antigen. The IA line and (CB x IA)F1 chickens develop severe inflammatory changes in brain and spinal cord tissues after immunization with SCT, whereas no such alterations occur in WA line chickens. Immunization with MP does not lead to histopathological changes in any chicken line investigated. MP, however, induces high production of specific IgM antibodies in all lines. IgG antibody levels are elevated only in IA line chickens after immunization with either antigen.
近交IA系鸡在用髓鞘碱性蛋白（MP）或脊髓组织（SCT）免疫后会出现实验性变应性脑脊髓炎（EAE）的临床症状。该疾病伴有惊厥以及翅膀和腿部麻痹。EAE导致IA系鸡100%死亡。另一方面，用任何一种抗原免疫后，WA系鸡和（CB×IA）F1代鸡均未出现临床症状。用SCT免疫后，IA系鸡和（CB×IA）F1代鸡的脑和脊髓组织出现严重炎症变化，而WA系鸡未出现此类改变。用MP免疫在所有研究的鸡系中均未导致组织病理学变化。然而，MP在所有品系中均诱导特异性IgM抗体的高产量。仅在用任何一种抗原免疫后，IA系鸡的IgG抗体水平升高。
