Oosterwijk E, Gillies R J
Department of Urology, 267 Experimental Urology, Radboud University Medical Center, , PO Box 9101, Nijmegen 6500 HB, The Netherlands.
Philos Trans R Soc Lond B Biol Sci. 2014 Feb 3;369(1638):20130107. doi: 10.1098/rstb.2013.0107. Print 2014 Mar 19.
The metabolism of cancer cells differs substantially from normal cells, including ion transport. Although this phenomenon has been long recognized, ion transporters have not been viewed as suitable therapeutic targets. However, the acidic pH values present in tumours which are well outside of normal limits are now becoming recognized as an important therapeutic target. Carbonic anhydrase IX (CAIX) is fundamental to tumour pH regulation. CAIX is commonly expressed in cancer, but lowly expressed in normal tissues and that presents an attractive target. Here, we discuss the possibilities of exploiting the acidic, hypoxic tumour environment as possible target for therapy. Additionally, clinical experience with CAIX targeting in cancer patients is discussed.
癌细胞的新陈代谢与正常细胞有很大不同，包括离子转运。尽管这一现象早已为人所知，但离子转运蛋白尚未被视为合适的治疗靶点。然而，肿瘤中存在的酸性pH值远远超出正常范围，现在正被认为是一个重要的治疗靶点。碳酸酐酶IX（CAIX）对肿瘤pH调节至关重要。CAIX在癌症中普遍表达，但在正常组织中表达较低，这使其成为一个有吸引力的靶点。在这里，我们讨论了利用酸性、缺氧的肿瘤环境作为可能的治疗靶点的可能性。此外，还讨论了针对癌症患者的CAIX靶向治疗的临床经验。
