免疫干扰素（AM3）可增强早期型干扰素诱导剂和自然杀伤细胞的活性。
Immunoferon (AM3) enhances the activities of early-type interferon inducers and natural killer cells.
作者信息
Moya P, Baixeras E, Barasoain I, Rojo J M, Ronda E, Alonso M L, Portolés A
机构信息
Centro de Investigaciones Biológicas C.S.I.C., Madrid, Spain.
出版信息
Immunopharmacol Immunotoxicol. 1987;9(2-3):243-56. doi: 10.3109/08923978709035213.
The "in vivo" effect of Immunoferon (AM3) on the production of interferon (IFN) and natural killer (NK) activity in young and old mice was studied. Although AM3 is not an IFN inducer by itself, enhancements in the serum IFN levels were produced when drug was associated to Newcastle disease virus or bacterial lipopolysaccharides as IFN inducers. This effect appeared to be dependent on the time lapsed between the inducer agent and drug. In addition, a significant stimulating effect on NK cell activity was also produced by AM3 treatments. This effect could be a consequence of a marked IFN induction and/or a modifying effect in prostaglandin synthesis.
研究了免疫干扰素（AM3）对年轻和老年小鼠体内干扰素（IFN）产生及自然杀伤（NK）活性的“体内”效应。尽管AM3本身不是干扰素诱导剂，但当该药物与作为干扰素诱导剂的新城疫病毒或细菌脂多糖联合使用时，血清干扰素水平会升高。这种效应似乎取决于诱导剂与药物之间的时间间隔。此外，AM3处理对NK细胞活性也有显著的刺激作用。这种效应可能是显著的干扰素诱导和/或前列腺素合成调节作用的结果。
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