细胞氧化还原平衡对核受体功能的调节。
Modulation of nuclear receptor function by cellular redox poise.
机构信息
Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.
Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.
出版信息
J Inorg Biochem. 2014 Apr;133:92-103. doi: 10.1016/j.jinorgbio.2014.01.005. Epub 2014 Jan 21.
Nuclear receptors (NRs) are ligand-responsive transcription factors involved in diverse cellular processes ranging from metabolism to circadian rhythms. This review focuses on NRs that contain redox-active thiol groups, a common feature within the superfamily. We will begin by describing NRs, how they regulate various cellular processes and how binding ligands, corepressors and/or coactivators modulate their activity. We will then describe the general area of redox regulation, especially as it pertains to thiol-disulfide interconversion and the cellular systems that respond to and govern this redox equilibrium. Lastly, we will discuss specific examples of NRs whose activities are regulated by redox-active thiols. Glucocorticoid, estrogen, and the heme-responsive receptor, Rev-erb, will be described in the most detail as they exhibit archetypal redox regulatory mechanisms.
核受体（NRs）是配体反应性转录因子，参与从代谢到生物钟节律等各种细胞过程。本综述重点介绍了含有氧化还原活性巯基的 NRs，这是该超家族的一个共同特征。我们将首先描述 NRs，它们如何调节各种细胞过程，以及配体、核心抑制剂和/或共激活剂如何调节它们的活性。然后，我们将描述氧化还原调节的一般领域，特别是与巯基-二硫键相互转化以及响应和控制这种氧化还原平衡的细胞系统有关的内容。最后，我们将讨论其活性受氧化还原活性巯基调节的特定 NRs 实例。糖皮质激素、雌激素和血红素反应受体 Rev-erb 将被详细描述，因为它们表现出典型的氧化还原调节机制。
Zotero 插件