White D M, Ehrhard P, Hardung M, Meyer D K, Zimmermann M, Otten U
II. Physiologisches Institut, Universität, Heidelberg, Federal Republic of Germany.
Naunyn Schmiedebergs Arch Pharmacol. 1987 Nov;336(5):587-90. doi: 10.1007/BF00169319.
In saphenous nerve neuromata of adult rats a long-term increase of immunoreactive nerve growth factor (irNGF) was detected after nerve transection. The occurrence of messenger RNA encoding NGF (NGF mRNA) in these proximal nerve stumps indicates local biosynthesis of NGF. In situ superfusion of neuromata revealed a constant release of irNGF which was significantly reduced by substance P (SP) but not affected by calcitonin gene related peptide (CGRP). We therefore suggest that SP may modulate the availability of NGF in the microenvironment of the regenerating nerve fiber endings.
在成年大鼠的隐神经神经瘤中，神经横断后检测到免疫反应性神经生长因子（irNGF）长期增加。这些近端神经残端中编码NGF的信使核糖核酸（NGF mRNA）的出现表明NGF的局部生物合成。神经瘤的原位超灌注显示irNGF持续释放，P物质（SP）可使其显著减少，但降钙素基因相关肽（CGRP）对其无影响。因此，我们认为SP可能调节再生神经纤维末梢微环境中NGF的可用性。
