肺功能参数作为晚期非小细胞肺癌的预后因素

Pulmonary function parameters as prognostic factors in advanced non-small cell lung cancer.

作者信息

Rančić Milan, Ristić Lidija, Rančić Snežana, Radović Milan, Ćirić Zorica

机构信息

Department for Pulmonary Oncology, Clinic for Lung Diseases, Clinical Center Niš, Serbia.

出版信息

Med Glas (Zenica). 2014 Feb;11(1):58-65.

PMID:24496342

Abstract

AIM

To investigate the impact of some parameters of lung function (forced expiratory volumen in 1 second - FEV1, forced vital capacity - FVC and ratio FEV1/FVC%) on survival in patients with advanced non-small cell lung cancer (NSCLC).

METHODS

It retrospectively analyzed data of 155 patients with NSCLC receiving second-line treatment in the Clinic for Lung Diseases, Clinical Center Nis, Serbia, from October 2009 to December 2012. Fifteen potential prognostic variables were subjected to univariate and multivariate analysis to investigate prognostic impact to survival.

RESULTS

Among the total of 155 patients, 124 (80%) were males. The most frequent was squamous carcinoma, 86 (55,5%). Mean FEV1 was 1.89 ± 0.71 L (61.8%), mean FVC 2.95 ± 0.8 L (77.2%) and mean FEV1/FVC% was 63.6%. In a multivariate analysis using Cox regression hazard model (hazard ratio, HR), independent prognostic factors for overall survival (OS) were: FEV1 less than 50% of predicted HR= 4.513, 95% confidence interval (CI): 1.433-14.216 (p=0.010), performance status 2 (HR= 0.090, CI= 0.035-0.230 (p=0.000) and weight loss more than 5 % (HR= 0.162, CI= 0.068-0.382 (p=0.000).

CONCLUSION

FEV1 in patients with advanced NSCLC receiving chemotherapy is an important independent factor that can predict survival. There was close relationship between impaired lung function and lung cancer patients survival.

摘要

目的

探讨肺功能的一些参数（一秒用力呼气容积 - FEV1、用力肺活量 - FVC 以及 FEV1/FVC%）对晚期非小细胞肺癌（NSCLC）患者生存率的影响。

方法

回顾性分析 2009 年 10 月至 2012 年 12 月期间在塞尔维亚尼斯临床中心肺病科接受二线治疗的 155 例 NSCLC 患者的数据。对 15 个潜在的预后变量进行单因素和多因素分析，以研究其对生存的预后影响。

结果

155 例患者中，124 例（80%）为男性。最常见的是鳞状细胞癌，共 86 例（55.5%）。平均 FEV1 为 1.89 ± 0.71 L（61.8%），平均 FVC 为 2.95 ± 0.8 L（77.2%），平均 FEV1/FVC%为 63.6%。在使用 Cox 回归风险模型（风险比，HR）的多因素分析中，总生存（OS）的独立预后因素为：FEV1 低于预测值的 50%，HR = 4.513，95%置信区间（CI）：1.433 - 14.216（p = 0.010），体能状态为 2（HR = 0.090，CI = 0.035 - 0.230，p = 0.000）以及体重减轻超过 5%（HR = 0.162，CI = 0.068 - 0.382，p = 0.000）。