Narayanan Ramanathan, Tuoc Tran Cong
Institute of Neuroanatomy, Universitätsmedizin Göttingen, Göttingen, Germany.
Cell Tissue Res. 2014 Jun;356(3):575-84. doi: 10.1007/s00441-013-1791-7. Epub 2014 Feb 5.
ATP-dependent BAF chromatin remodeling complexes play an essential role in the maintenance of the gene expression program by regulating the structure of chromatin. There is increasing evidence that BAF complexes based on the alternative ATPase subunits, Brg1 and Brm, control the differentiation of neural stem cells (NSCs) to generate distinct neural cell types and modulate trans-differentiation between cell types. The BAF complexes have dedicated functions at different stages of neural differentiation that appear to arise by combinatorial assembly of their subunits. Furthermore, the differentiation of NSCs is regulated by the tight interactions between the BAF chromatin remodeling complex and the transcriptional machinery. Here, we review recent insights into the functional interaction between BAF complexes and various transcription factors (TFs) in neural differentiation and cellular reprogramming.
ATP 依赖型 BAF 染色质重塑复合体通过调节染色质结构，在维持基因表达程序中发挥着至关重要的作用。越来越多的证据表明，基于替代 ATP 酶亚基 Brg1 和 Brm 的 BAF 复合体控制神经干细胞（NSC）的分化，以产生不同的神经细胞类型，并调节细胞类型之间的转分化。BAF 复合体在神经分化的不同阶段具有特定功能，这些功能似乎是由其亚基的组合组装产生的。此外，神经干细胞的分化受 BAF 染色质重塑复合体与转录机制之间紧密相互作用的调节。在这里，我们综述了近期关于 BAF 复合体与神经分化和细胞重编程中各种转录因子（TF）之间功能相互作用的见解。
