采用根治性剂量放疗治疗IV期宫颈癌。

The treatment of stage IV carcinoma of cervix by radical dose radiotherapy.

作者信息

Upadhyay S K, Symonds R P, Haelterman M, Watson E R

机构信息

Glasgow Institute of Radiotherapeutics and Oncology, Western Infirmary, Scotland, U.K.

出版信息

Radiother Oncol. 1988 Jan;11(1):15-9. doi: 10.1016/0167-8140(88)90042-4.

DOI:10.1016/0167-8140(88)90042-4

PMID:2449706

Abstract

During 1974-1979, 92 patients (14% of all carcinoma cervix cases) were assigned to Stage IV; 68 (10%) to Stage IVa and 24 (4%) to Stage IVb. Fifty-five patients were treated radically using 4 MeV X-rays (42.5 Gy in 20 fractions) followed by a 137Cs insertion (33.5 Gy to the A points). Twenty-six patients were treated palliatively and 11 received no treatment. Sixteen per cent of radically treated patients were alive at 5 years, whereas all patients treated palliatively were dead in 18 months. Pelvic tumour was eliminated in 22/55 (40%) treated radically, but in only 1/26 treated palliatively. The 5-year survival for Stage IVa treated radically was 18% and 19/44 (43%) had local tumour control. Only one patient in Stage IVb (involvement of vulva) was alive at 5 years. The overall 5-year survival for Stage IV patients in this series was 11/92 (12%).

摘要

在1974年至1979年期间，92例患者（占所有宫颈癌病例的14%）被归为IV期；其中68例（10%）为IVa期，24例（4%）为IVb期。55例患者接受了根治性治疗，采用4兆电子伏特的X射线（20次分割照射，总剂量42.5戈瑞），随后进行137铯植入（A点剂量33.5戈瑞）。26例患者接受了姑息性治疗，11例未接受治疗。根治性治疗的患者中有16%在5年后仍存活，而所有接受姑息性治疗的患者在18个月内均死亡。根治性治疗的55例患者中有22例（40%）盆腔肿瘤消失，而姑息性治疗的26例患者中只有1例。IVa期接受根治性治疗的患者5年生存率为18%，44例中有19例（43%）实现了局部肿瘤控制。IVb期（累及外阴）只有1例患者在5年后仍存活。该系列IV期患者的总体5年生存率为92例中的11例（12%）。