Fuller R W, Snoddy H D
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285.
Res Commun Chem Pathol Pharmacol. 1987 Dec;58(3):409-12.
8-Hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) decreased the concentration of 5-hydroxyindoleacetic acid (5HIAA), the deaminated metabolite of serotonin, in rat brain. 8-OH-DPAT was much more potent when injected subcutaneously than when injected intraperitoneally, the potency difference being approximately 17-fold. The important influence of route of administration on the potency of 8-OH-DPAT must be considered in interpreting the various functional effects that have been reported with it.
8-羟基-2-（二正丙基氨基）四氢萘（8-OH-DPAT）降低了大鼠脑中5-羟色胺的脱氨基代谢产物5-羟吲哚乙酸（5HIAA）的浓度。皮下注射时，8-OH-DPAT的效力比腹腔注射时强得多，效力差异约为17倍。在解释有关8-OH-DPAT的各种功能效应时，必须考虑给药途径对其效力的重要影响。
