造血干细胞生物学与移植中的信号转导及转录激活因子5（STAT5）
STAT5 in hematopoietic stem cell biology and transplantation.
作者信息
Wang Zhengqi, Bunting Kevin D
机构信息
Aflac Cancer and Blood Disorders Center; Children's Healthcare of Atlanta; Department of Pediatrics; Emory University School of Medicine; Atlanta, GA USA.
出版信息
JAKSTAT. 2013 Oct 1;2(4):e27159. doi: 10.4161/jkst.27159. Epub 2013 Nov 19.
Abstract
Signal transducer and activator of transcription 5 (STAT5) regulates normal lympho-myeloid development through activation downstream of early-acting cytokines, their receptors, and Janus kinases (JAKs). Despite a general understanding of the role of STAT5 in hematopoietic stem cell (HSC) proliferation, survival, and self-renewal, the transcriptional targets and mechanisms of gene regulation that control multi-lineage engraftment following transplantation for the most part remain to be understood. In this review, we focus on the role of STAT5 in HSC transplantation and recent developments toward identifying the relevant downstream target genes and their role as part of a pleiotropic STAT5 mediated signaling response.
摘要
信号转导及转录激活因子5（STAT5）通过早期作用细胞因子、其受体和Janus激酶（JAKs）下游的激活来调节正常的淋巴细胞-髓细胞发育。尽管人们对STAT5在造血干细胞（HSC）增殖、存活和自我更新中的作用有了大致了解，但在很大程度上，控制移植后多谱系植入的转录靶点和基因调控机制仍有待明确。在本综述中，我们重点关注STAT5在HSC移植中的作用，以及在鉴定相关下游靶基因及其作为多效性STAT5介导的信号反应一部分的作用方面的最新进展。
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