从滇西乌头根中分离出的三种新二萜生物碱。
Three new diterpenoid alkaloids from the roots of Aconitum duclouxii.
作者信息
Yin Tian-Peng, Cai Le, He Jian-Min, Dong Jian-Wei, Fang Hai-Xian, Zhou Hao, Ding Zhong-Tao
机构信息
a Key Laboratory of Medicinal Chemistry for Nature Resource , Ministry of Education, School of Chemical Science and Technology, Yunnan University , Kunming 650091 , China.
出版信息
J Asian Nat Prod Res. 2014;16(4):345-50. doi: 10.1080/10286020.2014.881802. Epub 2014 Feb 5.
Three new C₁₉-diterpenoid alkaloids, ducloudines C (1), D (2), and E (3), were isolated from the roots of Aconitum duclouxii. Their structures were established on the basis of extensive spectroscopic analyses. Ducloudine C (1) is the first aconitine-type C₁₉-diterpenoid alkaloid with a C=O group at C-3 and a C=C bond between C-1 and C-2. All compounds were tested for their biological activities against one pathogenic fungi and two pathogenic bacteria.
从滇西乌头的根中分离出三种新的C₁₉ - 二萜生物碱，即独龙云碱C（1）、D（2）和E（3）。它们的结构通过广泛的光谱分析得以确定。独龙云碱C（1）是首个在C - 3位具有C = O基团且在C - 1和C - 2之间具有C = C键的乌头碱型C₁₉ - 二萜生物碱。所有化合物均针对一种致病真菌和两种致病细菌进行了生物活性测试。
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