来自滇西乌头变种缠绕乌头的C19-二萜生物碱。

C19-diterpenoid alkaloids from Aconitum hemsleyanum var. circinatum.

作者信息

Gao Feng, Chen Qiao-Hong, Wang Feng-Peng

机构信息

Department of Chemistry of Medicinal Natural Products, West China College of Pharmacy, Sichuan University, No. 17, Duan 3, Renmin Nan Road, Chengdu 610041, People's Republic of China.

出版信息

J Nat Prod. 2007 May;70(5):876-9. doi: 10.1021/np0700117. Epub 2007 Apr 14.

DOI:10.1021/np0700117

PMID:17432903

Abstract

Seven new C19-diterpenoid alkaloids, circinasines A-G (1-7), together with six known compounds, talatisamine, yunaconitine, senbusine A, sachaconitine, hemsleyanisine, and isohemsleyanisine, were isolated from the roots of Aconitum hemsleyanum var. circinatum. The structures of 1-7 were determined by the interpretation of spectroscopic data and by the single-crystal X-ray crystallographic analysis of 6 and the acetonide derivative of 1. In addition, the structures of hemsleyanisine and isohemsleyanisine were revised from 8 and 9 to 10 and 11, respectively.

摘要

从卷叶乌头变种的根中分离得到7个新的C19 - 二萜生物碱，环乌宁碱A - G（1 - 7），以及6个已知化合物，塔拉地萨敏、云乌宁碱、森布辛A、沙可尼丁、滇乌碱和异滇乌碱。通过光谱数据解析以及对6和1的丙酮化物衍生物进行单晶X射线晶体学分析确定了1 - 7的结构。此外，滇乌碱和异滇乌碱的结构分别从8和9修正为10和11。