Johnson Daniel P, Whisman Mark A, Corley Robin P, Hewitt John K, Friedman Naomi P
a Department of Psychology and Neuroscience , University of Colorado Boulder , Boulder , CO , USA.
Cogn Emot. 2014;28(7):1270-86. doi: 10.1080/02699931.2014.881325. Epub 2014 Feb 5.
This study examined the extent to which rumination and depression share genetic and environmental influences in a community sample of adult twins (N=663). Twins completed multiple rumination questionnaires, a depressive symptoms questionnaire and a diagnostic interview. Rumination was moderately heritable (h2=.37-.41 for the latent variable) and substantially influenced by nonshared environmental factors, and these results were consistent across different measures. Nonshared environmental influences on rumination were larger for women than men. Depressive symptoms and diagnosis were influenced by genetic and nonshared environmental factors (h2=.30-.45). The genetic correlations between rumination and depression were moderate to large (rA=.40-.82), suggesting that a substantial proportion of the genetic influences on rumination overlap with those on depression. Results were similar when examining self-reported depressive symptoms and interview-based diagnosis of major depressive disorder. These results highlight the importance of rumination in the integration of cognitive and genetic models of depression risk.
本研究在一个成年双胞胎社区样本（N = 663）中，考察了沉思和抑郁在多大程度上共享遗传和环境影响。双胞胎完成了多个沉思问卷、一个抑郁症状问卷和一次诊断访谈。沉思具有中度遗传性（潜在变量的h2 = 0.37 - 0.41），并受到非共享环境因素的显著影响，且这些结果在不同测量方法中保持一致。非共享环境对沉思的影响女性大于男性。抑郁症状和诊断受到遗传和非共享环境因素的影响（h2 = 0.30 - 0.45）。沉思与抑郁之间的遗传相关性为中度至高度（rA = 0.40 - 0.82），表明对沉思的遗传影响中有很大一部分与对抑郁的遗传影响重叠。在检查自我报告的抑郁症状和基于访谈的重度抑郁症诊断时，结果相似。这些结果凸显了沉思在抑郁风险的认知和遗传模型整合中的重要性。
