电化学发光信号放大结合构象开关发夹 DNA 探针用于测定 Hsp53 肿瘤抑制基因的甲基化水平和位置。
Electrochemiluminescence signal amplification combined with a conformation-switched hairpin DNA probe for determining the methylation level and position in the Hsp53 tumor suppressor gene.
机构信息
Jiangsu Key Laboratory of New Power Batteries, Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210097, China.
出版信息
Chem Commun (Camb). 2014 Mar 18;50(22):2932-4. doi: 10.1039/c3cc49719d. Epub 2014 Feb 6.
PMID:24501739
Abstract
We report a new strategy for detection of the methylation level and position in the Hsp53 tumor suppressor gene based on the electrochemiluminescence signal amplification combined with a conformation-switched hairpin DNA probe for improving selectivity.
摘要
我们报道了一种新的策略，用于基于电化学发光信号放大和构象切换发夹 DNA 探针来提高选择性，以检测 Hsp53 肿瘤抑制基因的甲基化水平和位置。
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