Totev T, Tomov S, Gorchev G
Akush Ginekol (Sofiia). 2013;52(6):38-42.
Endometriosis is an estrogen-dependent, chronic gynecological disorder. Although endometriosis is a benign lesion, it shares several common characteristics with invasive cancer. Numerous epidemiologic studies indicate, that endometriosis patients have an increased risk of clear cell and endometrioid ovarian cancer. There is an intermediary lesion between endometriosis and malignant neoplasms - "atypical endometriosis". Genetic factors play a role in the malignant transformation through pathways related to oxidative stress, inflammation and hyperestrogenism.
子宫内膜异位症是一种雌激素依赖性慢性妇科疾病。尽管子宫内膜异位症是一种良性病变，但它与浸润性癌症有几个共同特征。大量流行病学研究表明，子宫内膜异位症患者患透明细胞癌和子宫内膜样卵巢癌的风险增加。在子宫内膜异位症和恶性肿瘤之间存在一种中间病变——“非典型子宫内膜异位症”。遗传因素通过与氧化应激、炎症和高雌激素血症相关的途径在恶性转化中起作用。
