Butov M A, Shurpo E M, Kuznetsov E M, Shelukhina S V
Eksp Klin Gastroenterol. 2013(5):36-41.
Despite the identical content of mebeverine hydrochloride, Duspatalin and Niaspam, produced by different technological processes, can't be considered interchangeable as they are known to have different clinical effect in case of various functional diseases of alimentary organs. Duspatalin is effective in relieving biliary disfunction symptoms, Oddy's sphincter hypertonicity in particular, but has little effect on intestinal dyskinesia. Niaspam is known to have little effect on biliary dyskinesia, but has a prominent positive clinical effect on intestinal dyskinesia.
尽管盐酸美贝维林、Duspatalin和Niaspam的成分相同，但由于它们是通过不同的工艺过程生产的，在消化系统的各种功能性疾病中具有不同的临床效果，因此不能认为它们可以互换使用。Duspatalin可有效缓解胆汁功能障碍症状，尤其是奥迪括约肌张力亢进，但对肠道运动障碍几乎没有效果。已知Niaspam对胆汁运动障碍几乎没有效果，但对肠道运动障碍有显著的积极临床效果。
