Petrushenko V V, Sukhodolia S A, Falalieieva T M, Berehova T V
Klin Khir. 2013 Dec(12):69-72.
Impact of rofecoxib on progressing of pancreatic fibrous changes in the rats in experimental chronic pancreatitis, caused by L-arginine, was studied up. In 60 male rats chronic pancreatitis was simulated, using intraabdominal L-arginine introduction (100 mg/100 g) through 21 days. Rofecoxib (5 mg/kg) was injected during 14 days to rats of the main group after L-arginine injections were completed. In 35 days of experiment the animals state, the pancreatic amylase and lipase activity in the blood serum, as well as morphological changes in pancreatic gland, were analyzed. Application of rofecoxib have had promoted the postponed pancreatic fibrosis formation, the morphofunctional state of pancreatic gland improvement. The data obtained constitute the experimental substantiation of possibility to apply nonsteroid antiinflammatory medicines in complex of clinical treatment of chronic pancreatitis.
研究了罗非昔布对L-精氨酸所致实验性慢性胰腺炎大鼠胰腺纤维化进展的影响。通过向60只雄性大鼠腹腔内注射L-精氨酸（100mg/100g），持续21天，模拟慢性胰腺炎。在完成L-精氨酸注射后，对主要组的大鼠注射罗非昔布（5mg/kg），持续14天。在实验的第35天，分析动物状态、血清中胰腺淀粉酶和脂肪酶活性以及胰腺的形态学变化。罗非昔布的应用促进了胰腺纤维化形成的延迟，改善了胰腺的形态功能状态。所获得的数据为在慢性胰腺炎临床治疗中联合应用非甾体抗炎药的可能性提供了实验依据。
