Sasaki K, Matsumura K, Tsuji T, Ogino T, Shinozaki F, Takahkshi M
Dept. of Pathology, Yamaguchi Univ. School of Med.
Gan No Rinsho. 1988 Feb;34(2):138-42.
The expression of the antigen recognized by a monoclonal antibody KM-93 has been examined in salivary gland tumors by means of an immunohistochemical technique. In immunoperoxidase staining, KM-93 reacted strongly with mucoepidermoid carcinomas and papillary adenocarcinomas, but not with adenoid cystic carcinomas. Thus, this antibody may not meet the requirements as a tumor marker. The inner duct-lining cells of a pleomorphic adenoma expressed the antigen whereas its outer myoepithelial cells did not. In normal glands, neither mucous glands nor myoepithelial cells reacted with the antibody but serous glands and ducts stained positive with the antibody. KM-93, it is thought, would be found useful for differential diagnosis and histogenetic studies of salivary gland tumors.
已通过免疫组织化学技术研究了单克隆抗体KM - 93所识别抗原在涎腺肿瘤中的表达情况。在免疫过氧化物酶染色中，KM - 93与黏液表皮样癌和乳头状腺癌反应强烈，但与腺样囊性癌无反应。因此，该抗体可能不符合作为肿瘤标志物的要求。多形性腺瘤的内导管衬里细胞表达该抗原，而其外肌上皮细胞不表达。在正常腺体中，黏液腺和肌上皮细胞均不与该抗体反应，但浆液腺和导管被该抗体染成阳性。据认为，KM - 93将有助于涎腺肿瘤的鉴别诊断和组织发生学研究。
