Reikerås O, Gunnes P
Institute of Medical Biology, University of Tromsø, Norway.
J Cardiovasc Pharmacol. 1987 Dec;10(6):643-6. doi: 10.1097/00005344-198712000-00006.
This study describes the effects of beta-receptor blockade on systemic hemodynamics and regional blood flows during acute ischemic heart failure in dogs. Depression of left ventricular (LV) function was induced by embolization of the left main coronary artery and was evidenced by a significant increase in LV end-diastolic pressure (LVEDP) and decrease in LV dP/dtmax and in cardiac output. Measurements of femoral, renal, mesenteric, and carotid blood flows showed a redistribution of cardiac output during failure. Femoral blood flow decreased to a greater extent than did cardiac output, carotid blood flow decreased in proportion to cardiac output, whereas mesenteric and renal blood flows were moderately reduced in relation to the decrease in cardiac output. Administration of 0.125 mg of propranolol intravenously (i.v.) significantly decreased the performance of the failing left ventricle. Reductions in cardiac output were accompanied by reductions in the peripheral circulations. The decrease in flow was evenly distributed in the femoral, mesenteric, and carotid vascular beds, while there was a relative preservation of renal blood flow. When the dose of propranolol was increased to 0.5 mg/kg, there were no further significant hemodynamic alterations.
本研究描述了β受体阻滞剂对犬急性缺血性心力衰竭期间全身血流动力学和局部血流的影响。通过栓塞左冠状动脉主干诱导左心室（LV）功能抑制，表现为LV舒张末期压力（LVEDP）显著升高、LV dP/dtmax和心输出量降低。股动脉、肾动脉、肠系膜动脉和颈动脉血流测量显示，心力衰竭期间心输出量发生重新分布。股动脉血流下降幅度大于心输出量，颈动脉血流与心输出量成比例下降，而肠系膜和肾血流相对于心输出量下降适度减少。静脉注射（i.v.）0.125 mg普萘洛尔显著降低了衰竭左心室的功能。心输出量降低伴随着外周循环的减少。血流减少均匀分布在股动脉、肠系膜动脉和颈动脉血管床，而肾血流相对保持。当普萘洛尔剂量增加至0.5 mg/kg时，血流动力学无进一步显著改变。
