Kozu Ryo, Jenkins Sue, Senjyu Hideaki
Department of Rehabilitation Medicine, Nagasaki University Hospital, Nagasaki, Japan; Physiotherapy Department, Sir Charles Gairdner Hospital, Perth, WA, Australia; School of Physiotherapy and Exercise Science, Curtin University, Perth, WA, Australia.
Physiotherapy Department, Sir Charles Gairdner Hospital, Perth, WA, Australia; School of Physiotherapy and Exercise Science, Curtin University, Perth, WA, Australia; Lung Institute of Western Australia and Centre for Asthma, Allergy and Respiratory Research, University of Western Australia, Perth, WA, Australia.
Arch Phys Med Rehabil. 2014 May;95(5):950-5. doi: 10.1016/j.apmr.2014.01.016. Epub 2014 Feb 3.
To investigate the relations between Medical Research Council (MRC) dyspnea grade and peripheral muscle force, activities of daily living (ADL) performance, health status, lung function, and exercise capacity in subjects with idiopathic pulmonary fibrosis (IPF).
Prospective cross-sectional observational study.
University hospital.
Subjects with IPF (N=65, 46 men) in a stable clinical state with a mean age of 68±7 years.
Not applicable.
Right ventricular systolic pressure (RVSP) via transthoracic echocardiography, pulmonary function, isometric quadriceps force (QF) and handgrip force (HF), 6-minute walk distance (6MWD), ADL score, and health status (Medical Outcomes Study 36-Item Short-Form Health Survey [SF-36]) were assessed and compared between subjects grouped according to MRC grade.
Of the participants, 16 were in MRC grade 2, 17 were in MRC grade 3, 17 were in MRC grade 4, and 15 were in MRC grade 5. RVSP, pulmonary function, QF, HF, 6MWD, ADL, and SF-36 scores decreased with increasing MRC grade (all P<.001). All measures were lower (P<.05) in subjects with grades 4 and 5 than subjects with grades 2 and 3. Strong associations were found between MRC grade and 6MWD (ρ=-.89, P=.001) and ADL score (ρ=-.82, P=.001). MRC grade was also associated with RVSP, pulmonary function, QF, and HF (all ρ≥.56, P=.001).
The MRC dyspnea scale provides a simple and useful method of categorizing individuals with IPF with respect to their activity limitation and may assist in understanding the impact of IPF on an individual.
探讨特发性肺纤维化（IPF）患者的医学研究委员会（MRC）呼吸困难分级与外周肌力、日常生活活动（ADL）能力、健康状况、肺功能及运动能力之间的关系。
前瞻性横断面观察性研究。
大学医院。
处于稳定临床状态的IPF患者（N = 65，46名男性），平均年龄68±7岁。
不适用。
通过经胸超声心动图测量右心室收缩压（RVSP）、肺功能、等长股四头肌肌力（QF）和握力（HF）、6分钟步行距离（6MWD）、ADL评分及健康状况（医学结局研究简明健康调查问卷36项版[SF - 36]），并在根据MRC分级分组的受试者之间进行评估和比较。
参与者中，16例为MRC 2级，17例为MRC 3级，17例为MRC 4级，15例为MRC 5级。随着MRC分级增加，RVSP、肺功能、QF、HF、6MWD、ADL及SF - 36评分均降低（均P <.001）。4级和5级受试者的所有测量指标均低于2级和3级受试者（P <.05）。MRC分级与6MWD（ρ = -.89，P =.001）和ADL评分（ρ = -.82，P =.001）之间存在强相关性。MRC分级还与RVSP、肺功能、QF和HF相关（均ρ≥.56，P =.001）。
MRC呼吸困难量表为对IPF患者的活动受限情况进行分类提供了一种简单且有用的方法，并可能有助于理解IPF对个体的影响。
