Tinhofer C, Widmann R, Pfaller W, Sperk G
Department of Pharmacology, University of Innsbruck, Austria.
Neurosci Lett. 1987 Dec 16;83(1-2):30-4. doi: 10.1016/0304-3940(87)90211-4.
Cysteamine (100 micrograms) markedly reduces the number (by about 60%) and intensity of staining of NADPH diaphorase-reactive neurons 6 h after local injection into the striatum. This effect was reversible (after 24 h) and was only observed when the indirect staining procedure was applied in which NADPH formed by endogenous malate dehydrogenase is used. However, no direct effect of cysteamine on the malate dehydrogenase reaction was found. The decrease in NADPH diaphorase activity parallels the previously reported cysteamine induced decrease in somatostatin contained in the same neurons and may point to a biochemical interrelation of somatostatin and NADPH diaphorase in these neurons.
半胱胺（100微克）在局部注射到纹状体6小时后，可显著减少NADPH黄递酶反应性神经元的数量（约减少60%）和染色强度。这种效应是可逆的（24小时后），并且只有在采用间接染色程序（即使用内源性苹果酸脱氢酶形成的NADPH）时才会观察到。然而，未发现半胱胺对苹果酸脱氢酶反应有直接影响。NADPH黄递酶活性的降低与先前报道的半胱胺诱导的相同神经元中生长抑素的减少平行，这可能表明这些神经元中生长抑素与NADPH黄递酶之间存在生化相互关系。
