*Laservision.gr Eye Institute, Athens, Greece; and †Department of Ophthalmology, New York University Medical School, New York, NY.
Cornea. 2014 Apr;33(4):340-8. doi: 10.1097/ICO.0000000000000053.
The aim of this study was to evaluate via Fourier-domain anterior-segment optical coherence tomography 3-dimensional corneal, epithelial, and graft thickness changes after Descemet stripping automated endothelial keratoplasty (DSAEK).
Sixteen eyes were investigated preoperatively and up to 6 months postoperatively for preoperative and postoperative central corneal thickness (CCT), minimum corneal thickness, central graft thickness (CGT), and for epithelial topographic thickness variability. An age-matched and gender-matched control group of 32 healthy eyes was used for comparison.
In the DSAEK group, the preoperative CCT was 582.32 ± 45.24 (550-615) μm. One-month postoperatively, the CCT was 736.26 ± 34.52 (713-771) μm, and the CGT was 210.42 ± 34.52 (145-243) μm. Three months postoperatively, the CCT was 641.39 ± 38.75 (569-684) μm, and the CGT was 171.23 ± 27.54 (119-185) μm. The preoperative center epithelial thickness was 55.74 ± 9.29 (45-74) μm, the minimum was 32.53 ± 14.30 (13-53) μm, the maximum was 76.00 ± 11.32 (64-105) μm, and the topographic thickness variability was 10.84 ± 4.09 (5.90-18.80) μm. Three months postoperatively, the center epithelial thickness was 47.21 ± 5.45 (43-56) μm, the minimum was 35.11 ± 4.70 (30-41) μm, the maximum was 58.11 ± 6.51 (49-65) μm, and the topographic variability was 4.77 ± 1.48 (2.90-6.50) μm. The average differences were -8.53, +4.53, and -17.89 μm for the center, minimum, and maximum (P < 0.001, <0.001, and <0.001). Similar results were obtained 3 and 6 months postoperatively.
We present a near-term postoperative investigation of the corneal and epithelial thickness changes after DSAEK for bullous keratopathy, by in vivo, clinical anterior-segment optical coherence tomography. Epithelial thickness recovery and normalization and corneal deturgescence were noted as early as in the first postoperative month.
本研究旨在通过傅里叶域眼前节光学相干断层扫描（OCT）评估去表皮化自动内皮角膜移植术（DSAEK）后角膜、上皮和移植物厚度的三维变化。
术前和术后 6 个月对 16 只眼进行研究，以评估术前和术后中央角膜厚度（CCT）、最小角膜厚度、中央移植物厚度（CGT）和上皮地形图厚度变异性。使用 32 只年龄和性别匹配的健康眼作为对照组进行比较。
在 DSAEK 组中，术前 CCT 为 582.32±45.24μm（550-615μm）。术后 1 个月，CCT 为 736.26±34.52μm（713-771μm），CGT 为 210.42±34.52μm（145-243μm）。术后 3 个月，CCT 为 641.39±38.75μm（569-684μm），CGT 为 171.23±27.54μm（119-185μm）。术前中央上皮厚度为 55.74±9.29μm（45-74μm），最小厚度为 32.53±14.30μm（13-53μm），最大厚度为 76.00±11.32μm（64-105μm），地形图厚度变异性为 10.84±4.09μm（5.90-18.80μm）。术后 3 个月，中央上皮厚度为 47.21±5.45μm（43-56μm），最小厚度为 35.11±4.70μm（30-41μm），最大厚度为 58.11±6.51μm（49-65μm），地形图变异性为 4.77±1.48μm（2.90-6.50μm）。中央、最小和最大上皮厚度的平均差异分别为-8.53μm、+4.53μm 和-17.89μm（P＜0.001、＜0.001 和＜0.001）。术后 3 个月和 6 个月也获得了类似的结果。
我们通过活体眼前节 OCT 对大泡性角膜病变行 DSAEK 术后的角膜和上皮厚度变化进行了近远期术后评估。在术后第一个月就已经注意到上皮厚度的恢复和正常化以及角膜的脱水。
