Santos-Gallego Carlos G, Picatoste Belen, Badimón Juan José
Atherothrombosis Research Unit, The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, One Gustave Levy Place, Box 1030, New York, NY, 10029, USA.
Curr Atheroscler Rep. 2014 Apr;16(4):401. doi: 10.1007/s11883-014-0401-9.
Despite improvements in interventional and pharmacological therapy for atherosclerotic disease, it is still the leading cause of death in the developed world. Hence, there is a need for further development of more effective therapeutic approaches. This requires better understanding of the molecular mechanisms and pathophysiology of the disease. Recent research in the last decade has changed our view of acute coronary syndrome (ACS): from a mere lipid deposition to an inflammatory disease; from ACS exclusively due to plaque rupture to the novel definitions of plaque erosion or calcified nodule; from the notion of a superimposed thrombus with necessary lethal consequences to the concept of healed plaques and thrombus contributing to plaque progression. In the hope of improving our understanding of ACS, all these recently discovered concepts are reviewed in this article.
尽管动脉粥样硬化疾病的介入治疗和药物治疗有所改进，但它仍是发达国家的主要死因。因此，需要进一步开发更有效的治疗方法。这需要更好地理解该疾病的分子机制和病理生理学。过去十年的最新研究改变了我们对急性冠状动脉综合征（ACS）的看法：从单纯的脂质沉积到炎症性疾病；从仅由斑块破裂导致的ACS到斑块侵蚀或钙化结节的新定义；从叠加血栓必然导致致命后果的观念到愈合斑块和血栓促进斑块进展的概念。为了增进我们对ACS的理解，本文对所有这些最近发现的概念进行了综述。
