Xie Xuena, Huang Meiwen, Ma Shudong, Xin Qiqi, Wang Yuying, Hu Lantian, Zhao Han, Li Pengqi, Liu Mei, Yuan Rong, Miao Yu, Zhu Yizhun, Cong Weihong
School of Pharmacy, Faculty of Medicine, Macau University of Science and Technology, Macau SAR, 999078, China.
Laboratory of Cardiovascular Diseases, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.
Noncoding RNA Res. 2024 Dec 28;11:158-187. doi: 10.1016/j.ncrna.2024.12.009. eCollection 2025 Apr.
Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality worldwide, posing significant challenges to healthcare systems. Despite advances in medical interventions, the molecular mechanisms underlying CVDs are not yet fully understood. For decades, protein-coding genes have been the focus of CVD research. However, recent advances in genomics have highlighted the importance of long non-coding RNAs (lncRNAs) in cardiovascular health and disease. Changes in lncRNA expression specific to tissues may result from various internal or external factors, leading to tissue damage, organ dysfunction, and disease. In this review, we provide a comprehensive discussion of the regulatory mechanisms underlying lncRNAs and their roles in the pathogenesis and progression of CVDs, such as coronary heart disease, atherosclerosis, heart failure, arrhythmias, cardiomyopathies, and diabetic cardiomyopathy, to explore their potential as therapeutic targets and diagnostic biomarkers.
心血管疾病（CVDs）是全球发病和死亡的主要原因，给医疗保健系统带来了重大挑战。尽管医学干预取得了进展，但CVDs潜在的分子机制尚未完全明确。几十年来，蛋白质编码基因一直是CVD研究的重点。然而，基因组学的最新进展突出了长链非编码RNA（lncRNAs）在心血管健康和疾病中的重要性。特定组织中lncRNA表达的变化可能由各种内部或外部因素引起，导致组织损伤、器官功能障碍和疾病。在本综述中，我们全面讨论了lncRNAs的调控机制及其在冠心病、动脉粥样硬化、心力衰竭、心律失常、心肌病和糖尿病性心肌病等CVDs发病机制和进展中的作用，以探索它们作为治疗靶点和诊断生物标志物的潜力。
