Hwang Young Hoon, Kim Yong Yeon, Kim Hwang Ki, Sohn Yong Ho
Department of Ophthalmology, Konyang University, Kim's Eye Hospital, Myung-Gok Eye Research Institute, , Seoul, Korea.
Br J Ophthalmol. 2014 May;98(5):669-74. doi: 10.1136/bjophthalmol-2013-303931. Epub 2014 Feb 6.
BACKGROUND/AIMS: To investigate the effect of peripapillary retinoschisis on the peripapillary retinal nerve fibre layer (RNFL) thickness measurement by using optical coherence tomography (OCT) in glaucomatous eyes.
We included 19 glaucomatous eyes of 19 subjects with peripapillary retinoschisis defined as the splitting of the peripapillary RNFL with schisis cavities (retinoschisis group) and 38 age-matched, refractive error-matched and visual field mean deviation-matched glaucomatous eyes from 38 subjects without peripapillary retinoschisis (control group) that had undergone RNFL thickness measurements by using OCT. RNFL thickness was compared between the two groups. For the retinoschisis group, the RNFL thicknesses prior to peripapillary retinoschisis formation, at the time of peripapillary retinoschisis, and after peripapillary retinoschisis resolution were compared.
The average RNFL was greater in the eyes in the retinoschisis group (median, 81.6 µm) than in those in the control group (median, 69.7 µm, p=0.009). In the retinoschisis group, the average RNFL thickness at the time of peripapillary retinoschisis was greater than that prior to peripapillary retinoschisis formation (p=0.013) or after peripapillary retinoschisis resolution (p=0.001). The RNFL thickness was not different prior to peripapillary retinoschisis formation and after peripapillary retinoschisis resolution (p>0.05).
Transient increase in RNFL thickness as determined by OCT was observed in glaucomatous eyes with peripapillary retinoschisis. Caution is warranted when interpreting the RNFL thickness measurement in eyes with peripapillary retinoschisis.
背景/目的：探讨青光眼患者中视乳头周围视网膜劈裂对视乳头周围视网膜神经纤维层（RNFL）厚度光学相干断层扫描（OCT）测量结果的影响。
我们纳入了19例患有视乳头周围视网膜劈裂的青光眼患者的19只眼睛（视网膜劈裂组），视乳头周围视网膜劈裂定义为视乳头周围RNFL出现劈裂腔；以及38例年龄匹配、屈光不正匹配且视野平均偏差匹配的青光眼患者的38只眼睛（对照组），这些患者未发生视乳头周围视网膜劈裂，均接受了RNFL厚度的OCT测量。比较两组的RNFL厚度。对于视网膜劈裂组，比较视乳头周围视网膜劈裂形成前、视乳头周围视网膜劈裂时以及视乳头周围视网膜劈裂消退后的RNFL厚度。
视网膜劈裂组眼睛的平均RNFL（中位数，81.6 µm）大于对照组（中位数，69.7 µm，p = 0.009）。在视网膜劈裂组中，视乳头周围视网膜劈裂时的平均RNFL厚度大于视乳头周围视网膜劈裂形成前（p = 0.013）或视乳头周围视网膜劈裂消退后（p = 0.001）。视乳头周围视网膜劈裂形成前和视乳头周围视网膜劈裂消退后的RNFL厚度无差异（p>0.05）。
在患有视乳头周围视网膜劈裂的青光眼患者眼中，观察到OCT测定的RNFL厚度短暂增加。在解释视乳头周围视网膜劈裂患者的RNFL厚度测量结果时应谨慎。
