HIV 感染婴儿和幼儿的抗逆转录病毒治疗：密西西比婴儿提出的新问题。
Antiretroviral treatment in HIV-infected infants and young children: novel issues raised by the Mississippi baby.
机构信息
Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
出版信息
Expert Rev Anti Infect Ther. 2014 Mar;12(3):307-18. doi: 10.1586/14787210.2014.888311. Epub 2014 Feb 9.
Abstract
The recent case report of an HIV-infected child in Mississippi with viral control post-antiretroviral therapy (ART) interruption has sparked interest in the possibility of 'functional cure' in infants if they initiate ART very soon after birth. The 'Mississippi baby' also raises many new questions around the clinical care of HIV-infected infants and young children, including when treatment should be initiated, why treatment should be initiated, what treatment should be initiated, and how to identify infants early enough to treat them adequately. Here, we review research conducted before the report of the 'Mississippi baby' highlighting the important new issues that now need to be taken into consideration.
摘要
最近，密西西比州一名感染艾滋病毒的儿童在中断抗逆转录病毒治疗（ART）后病毒得到控制的病例报告引起了人们的兴趣，如果婴儿在出生后不久就开始接受 ART，那么他们有可能实现“功能性治愈”。“密西西比婴儿”也引发了许多有关感染艾滋病毒的婴儿和幼儿临床护理的新问题，包括何时开始治疗、为何要开始治疗、应启动何种治疗，以及如何及早发现婴儿并为他们提供充分的治疗。在这里，我们回顾了“密西西比婴儿”报告之前进行的研究，重点介绍了现在需要考虑的重要新问题。
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