Xiong Kun, Wang Linlin, Chen Xulin, Cao Yongqian, Xiang Chuan, Xue Lixiang, Yan Zhangcai
Department of Health Science, National Natural Science Foundation of China, Beijing 100085, China. Corresponding author: Yan Zhangcai, Email:
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2014 Jan;26(1):11-6. doi: 10.3760/cma.j.issn.2095-4352.2014.01.003.
To summarized the projects received and funded in the fields of emergency and intensive care medicine/trauma/burns/plastic surgery from National Natural Science Foundation of China (NSFC) during 2010-2013, put forward the thinking and perspective of this future trend in these fields.
The number of the funded project and total funding in the fields of emergency and intensive care medicine/trauma/burns/plastic surgery from NSFC during 2010-2013 had been statistical analyzed, in the meantime, the overview situation of various branches in basic research and further preliminary analysis the research frontier and hot issues have been analyzed.
(1) The number of funded project were 581 in H15 of NSFC during 2010-2013, total funding reached to 277.13 million RMB, including 117 projects in H1511 (emergency and intensive care medicine/trauma/burns/plastic surgery and other science issue), 96 projects in H1507 (wound healing and scar), 88 projects in H1502 (multi-organ failure), 71 projects in H1505 (burn), 61 projects in H1504 (trauma). (2) The top 10 working unit for project funding in the field of emergency and intensive care medicine/trauma/burns/plastic surgery present as Third Military Medical University (70), Shanghai Jiao tong University (69), Second Military Medical University (40), Chinese PLA General Hospital (36), Forth Military Medical University (35), Zhejiang University (22), Sun Yat-Sen University (18), Southern Medical University (14), China Medical University (11), Capital Medical University (11) respectively, the number of funded project positive correlated with funding. (3) The funded research field in H15 covered almost all important organs and system injury or repair research, our scientists reached a fairly high level in some research field, for example, sepsis, trauma, repair, et al. "Sepsis" was funded 112 projects in H15 for 4 years, the growth rate became rapid and stable comparing to shock, burns and cardiopulmonary resuscitation funded projects' number. "Emergency and intensive care medicine/trauma/burns" research fields related to heart, lung, bone/cartilage/muscle, stomach/intestinal/liver, brain/spinal cord/peripheral nerve and other tissues/organs. The number of funded projects in plastic surgery related research fields in angioma and flap related projects were down below to 3 projects, but the number of funded project in wounds, scar repair related research field were more than other fields relatively. (4) In frontier and research hot issue, the funded rate represent as 23.8%, 21.4%, 19.0% and 23.9% in stem cell related research fields in 4 years respectively. The funded rate average to 20.9% in epigenetic related research fields for four years, the funded rate achieved to break through "zero" in autophagy related research fields, the total rate raised to 32.6% from 2011 to 2013.
The funded number and funding were raised rapidly in the fields of emergency and intensive care medicine/trauma/burns/plastic surgery from NSFC. The application for each proposal should be focus on concise or upgrade the scientific issues to improve the quality. The depth or systematic in content and interdisciplinary research fields (e.g. immunology) should be paid attention to. Sepsis, trauma and burns will be the main stream direction in future in the fields of emergency and intensive care medicine/trauma/burns/plastic surgery. The fields of wound healing and scar, surface organ defects, damage, repair and regeneration, surface tissue/organ transplantation and reconstruction, craniofacial deformities and correction are important develop directions in future work.
总结2010 - 2013年国家自然科学基金(NSFC)资助的急诊与重症医学/创伤/烧伤/整形外科学领域的项目情况,提出该领域未来发展趋势的思考与展望。
对2010 - 2013年NSFC资助的急诊与重症医学/创伤/烧伤/整形外科学领域的项目数量和资助总额进行统计分析,同时分析各分支基础研究概况并初步探讨研究前沿与热点问题。
(1)2010 - 2013年NSFC的H15类资助项目共581项,资助总额达2.7713亿元人民币,其中H1511(急诊与重症医学/创伤/烧伤/整形外科学及其他科学问题)117项,H1507(伤口愈合与瘢痕)96项,H1502(多器官功能衰竭)88项,H1505(烧伤)71项,H1504(创伤)61项。(2)急诊与重症医学/创伤/烧伤/整形外科学领域项目资助排名前10的工作单位依次为第三军医大学(70项)、上海交通大学(69项)、第二军医大学(40项)、中国人民解放军总医院(36项)、第四军医大学(35项)、浙江大学(22项)、中山大学(18项)、南方医科大学(14项)、中国医科大学(11项)、首都医科大学(11项),资助项目数与资助金额呈正相关。(3)H15资助研究领域涵盖了几乎所有重要器官和系统的损伤或修复研究,我国科学家在一些研究领域达到了较高水平,如脓毒症、创伤修复等。“脓毒症”4年内在H15类获资助112项,与休克、烧伤和心肺复苏资助项目数相比,增长迅速且稳定。“急诊与重症医学/创伤/烧伤”研究领域涉及心、肺、骨/软骨/肌肉、胃/肠/肝、脑/脊髓/周围神经等组织器官。整形外科学相关研究领域中血管瘤和皮瓣相关项目资助数降至3项以下,但伤口、瘢痕修复相关研究领域资助项目数相对较多。(4)在前沿与研究热点问题方面,干细胞相关研究领域4年资助率分别为23.8%、21.4%、19.0%和23.9%。表观遗传学相关研究领域4年资助率平均为20.9%,自噬相关研究领域资助率实现突破“零”,2011 - 2013年总资助率升至32.6%。
NSFC资助的急诊与重症医学/创伤/烧伤/整形外科学领域项目数量和资助金额增长迅速。各项目申请应注重凝练或提升科学问题以提高质量,关注研究内容的深度或系统性以及跨学科研究领域(如免疫学)。脓毒症、创伤和烧伤将是急诊与重症医学/创伤/烧伤/整形外科学领域未来的主流方向。伤口愈合与瘢痕、体表器官缺损、损伤、修复与再生、体表组织/器官移植与重建、颅面部畸形与矫治等领域是未来工作的重要发展方向。